Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 27;15(4):419–430. doi: 10.1080/15592294.2019.1695333

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

PMC Copyright notice

Figure 2. — Validation of the DNA methylation biomarker set on independent cancer sample cohorts from the GEO. Normal whole blood cohort (GSE72773) and respective normal tissues (NT) were used as controls. The plots show DNA methylation of the marker set in individual tumour samples in comparison to normal blood samples and respective NT samples. The samples were classified as tumours or normal based on the metadata from GEO. The x-axis indicates individual samples. The y-axis shows cumulative beta values for the entire marker set and the individual markers in the set are distinguished by colours. The DNA methylation data from the normal blood cohort are shown only in the first panel and are represented in the additional panels by the horizontal dashed lines showing the 95th percentile of the cumulative DNA methylation of the normal blood cohort. The horizontal dotted lines indicate the 95th percentiles of the cumulative DNA methylation of the respective NT cohorts. The AUCs were calculated using the cumulative beta values for the entire marker set for each sample from the respective tumour cohort and the normal blood cohort or respective NT as a normal reference for each cancer type.