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. 2019 Dec 16;15(4):398–418. doi: 10.1080/15592294.2019.1695332

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Abundance and genomic distribution of 5hmC in breast tissue. (a) Cumulative density distributions of median 5hmC and 5mC methylation beta-values breast tissue (n= 18). (b) Cumulative density distributions of Pearson and Spearman correlation coefficients as calculated for the relationship between 5hmC and 5mC beta-values at each CpG loci across all breast tissues (n= 18). Percentiles of median 5mC (c) and 5hmC (d) beta-values as calculated across all breast tissues and stratified by CpG island context (islands, shores, shelves, and open sea regions).