Table 1.
Selected biological processes and pathways deregulated after inhalation of CuO NPs.
| ID | Deregulated Biological Process/Pathway | q-Value | Deregulated Genes (N) | Genes in Pathway (N) |
|---|---|---|---|---|
| 3 Days | ||||
| GO:0030574 | collagen catabolic process | 0.003 | 7 | 67 |
| GO:0043062 | extracellular structure organization | 0.005 | 13 | 355 |
| GO:0030198 | extracellular matrix organization | 0.005 | 13 | 354 |
| GO:0032963 | collagen metabolic process | 0.028 | 7 | 122 |
| GO:0061077 | chaperone-mediated protein folding | 0.028 | 5 | 52 |
| 1269985 | Chondroitin sulfate biosynthesis | 0.009 | 4 | 22 |
| 82982 | Glycosaminoglycan biosynthesis - chondroitin sulfate/dermatan sulfate | 0.009 | 4 | 20 |
| 545276 | chondroitin sulfate biosynthesis (late stages) | 0.009 | 3 | 8 |
| 1270245 | Collagen formation | 0.019 | 6 | 93 |
| 1270247 | Assembly of collagen fibrils and other multimeric structures | 0.019 | 5 | 60 |
| 2 Weeks | ||||
| GO:0006955 | immune response | < 0.001 | 165 | 1572 |
| GO:0002682 | regulation of immune system process | < 0.001 | 140 | 1506 |
| GO:0006952 | defense response | < 0.001 | 142 | 1651 |
| GO:0002684 | positive regulation of immune system process | < 0.001 | 102 | 976 |
| GO:0001775 | cell activation | < 0.001 | 96 | 1001 |
| 1269203 | Innate Immune System | < 0.001 | 101 | 1312 |
| 1470924 | Interleukin-10 signaling | < 0.001 | 21 | 49 |
| 83051 | Cytokine-cytokine receptor interaction | < 0.001 | 41 | 270 |
| 1457780 | Neutrophil degranulation | < 0.001 | 50 | 492 |
| 1269310 | Cytokine Signaling in Immune system | < 0.001 | 64 | 763 |
| 6 Weeks | ||||
| GO:0006955 | immune response | < 0.001 | 122 | 1572 |
| GO:0002682 | regulation of immune system process | < 0.001 | 113 | 1506 |
| GO:0006954 | inflammatory response | < 0.001 | 76 | 711 |
| GO:0006952 | defense response | < 0.001 | 115 | 1651 |
| GO:0001816 | cytokine production | < 0.001 | 70 | 700 |
| 1269203 | Innate Immune System | < 0.001 | 97 | 1312 |
| 1457780 | Neutrophil degranulation | < 0.001 | 56 | 492 |
| 1470924 | Interleukin-10 signaling | < 0.001 | 17 | 49 |
| M5889 | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins | < 0.001 | 70 | 1028 |
| M5885 | Ensemble of genes encoding ECM-associated proteins including ECM-affiliated proteins, ECM regulators and secreted factors | < 0.001 | 57 | 753 |
| 3 Months | ||||
| GO:0006955 | immune response | < 0.001 | 282 | 1572 |
| GO:0006952 | defense response | < 0.001 | 277 | 1651 |
| GO:0051240 | positive regulation of multicellular organismal process | < 0.001 | 260 | 1610 |
| GO:0002682 | regulation of immune system process | < 0.001 | 249 | 1506 |
| GO:0001816 | cytokine production | < 0.001 | 154 | 700 |
| 1269203 | Innate Immune System | < 0.001 | 210 | 1312 |
| 1457780 | Neutrophil degranulation | < 0.001 | 105 | 492 |
| 1269310 | Cytokine Signaling in Immune system | < 0.001 | 125 | 763 |
| 1470924 | Interleukin-10 signaling | < 0.001 | 25 | 49 |
| 83051 | Cytokine-cytokine receptor interaction | < 0.001 | 62 | 270 |