Table 2.

Selected unique biological processes deregulated after inhalation of CuO NPs.

ID	Deregulated Biological Process	q-Value	Deregulated Genes (N)	Genes in Pathway (N)
2 Weeks
GO:0006955	immune response	0.019	33	1572
GO:0045776	negative regulation of blood pressure	0.019	6	56
GO:0010941	regulation of cell death	0.019	33	1650
GO:0002682	regulation of immune system process	0.019	31	1506
GO:0043067	regulation of programmed cell death	0.022	31	1536
GO:0002683	negative regulation of immune system process	0.022	14	420
GO:0012501	programmed cell death	0.022	36	1952
GO:0001775	cell activation	0.025	23	1001
GO:0042981	regulation of apoptotic process	0.025	30	1519
GO:0006915	apoptotic process	0.027	35	1923
GO:0006955	immune response	0.019	33	1572
6 Weeks
GO:0000280	nuclear division	< 0.001	24	599
GO:0048285	organelle fission	< 0.001	24	636
GO:1903047	mitotic cell cycle process	< 0.001	26	931
GO:0000278	mitotic cell cycle	< 0.001	27	1016
GO:0022402	cell cycle process	< 0.001	32	1385
GO:0000070	mitotic sister chromatid segregation	< 0.001	10	136
GO:0051241	negative regulation of multicellular organismal process	0.001	27	1127
GO:0051301	cell division	0.001	20	668
GO:0007049	cell cycle	0.001	35	1766
GO:0055118	negative regulation of cardiac muscle contraction	0.001	3	4
3 Months
GO:0051240	positive regulation of multicellular organismal process	< 0.001	171	1610
GO:0022610	biological adhesion	< 0.001	164	1542
GO:0007155	cell adhesion	< 0.001	161	1530
GO:0040011	locomotion	< 0.001	170	1735
GO:0016477	cell migration	< 0.001	137	1300
GO:0001816	cytokine production	< 0.001	90	700
GO:0051674	localization of cell	< 0.001	141	1428
GO:0048870	cell motility	< 0.001	141	1428
GO:0006928	movement of cell or subcellular component	< 0.001	170	1882
GO:0009611	response to wounding	< 0.001	106	967
GO:0051240	positive regulation of multicellular organismal process	< 0.001	171	1610