Table 4.

Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways based on miRNA–mRNA interactions deregulated after inhalation of CuO NPs.

ID	Deregulated Biological Process/Pathway	q-Value	Deregulated Genes (N)	Genes in Pathway (N)
3 Days
mmu04510	Focal adhesion	<0.001	19	199
mmu04512	ECM receptor interaction	<0.001	11	88
mmu05200	Pathways in cancer	0.003	21	539
2 Weeks
mmu04520	Adherens junction	<0.001	27	71
mmu04510	Focal adhesion	<0.001	44	199
mmu04270	Vascular smooth muscle contraction	<0.001	29	140
mmu04360	Axon guidance	<0.001	30	180
mmu04916	Melanogenesis	<0.001	24	100
mmu05414	Dilated cardiomyopathy	<0.001	23	94
mmu05200	Pathways in cancer	<0.001	51	539
mmu04330	Notch signaling pathway	<0.001	16	54
mmu04540	Gap junction	<0.001	21	86
mmu04810	Regulation of actin cytoskeleton	<0.001	36	216
mmu04740	Olfactory transduction	<0.001	5	1134
mmu04912	GnRH signaling pathway	<0.001	21	90
mmu04310	Wnt signaling pathway	<0.001	26	162
mmu05217	Basal cell carcinoma	<0.001	14	63
mmu04020	Calcium signaling pathway	0.001	27	192
mmu05410	Hypertrophic cardiomyopathy (HCM)	0.001	17	91
mmu04512	ECM receptor interaction	0.002	16	88
mmu05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0.002	15	77
mmu05213	Endometrial cancer	0.003	11	58
mmu04144	Endocytosis	0.003	27	269
mmu11190	Dorso-ventral axis formation	0.005	7	22
mmu05211	Renal cell carcinoma	0.005	13	68
mmu05016	Huntingtons disease	0.005	25	199
mmu04720	Long term potentiation	0.006	13	67
mmu04260	Cardiac muscle contraction	0.010	14	86
6 Weeks
mmu04142	Lysosome	<0.001	23	124
3 Months
mmu04142	Lysosome	<0.001	43	124
mmu04740	Olfactory transduction	<0.001	4	1134
mmu04060	Cytokine-cytokine receptor interaction	<0.001	60	296
mmu05140	Leishmania infection	<0.001	27	69
mmu04062	Chemokine signaling pathway	<0.001	45	198
mmu04650	Natural killer cell mediated cytotoxicity	<0.001	34	117
mmu04612	Antigen processing and presentation	<0.001	23	91
mmu05332	Graft versus host disease	<0.001	15	65
mmu04662	B cell receptor signaling pathway	<0.001	22	82
mmu04666	Fc gamma R-mediated phagocytosis	<0.001	26	90
mmu04620	Toll like receptor signaling pathway	<0.001	25	99
mmu05330	Allograft rejection	<0.001	14	63
mmu16848	Epithelial cell signaling in helicobacter pylori infection	<0.001	21	69
mmu04940	Type I diabetes mellitus	<0.001	15	70
mmu04664	Fc epsilon RI signaling pathway	0.001	20	67
mmu05320	Autoimmune thyroid disease	0.002	14	78
mmu05416	Viral myocarditis	0.006	17	88
mmu04660	T cell receptor signaling pathway	0.006	23	103
mmu04640	Hematopoietic cell lineage	0.008	18	95
mmu04672	Intestinal immune network for IgA production	0.009	12	42