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The virally encoded oncogene vGPCR induces the HO-1 promoter through a signaling pathway that involves the transcription factor Nrf2 activated through heterotrimeric as well as small GTP-binding proteins. The involvement of MAPK signaling as discussed in the main text is indicated by arrows [Adapted from Sapochnik et al. (59)]. vGPCR, G protein-coupled receptor encoded by KSHV. Color images are available online.
