Table 2.

Proposed efficacy Parameters for Target Product Profiles of Gene Drive-Modified Mosquitoes

1. Homing rate—predictor of rate of spread and time to impact

a. Deviation from Mendelian expectation of inheritance in cages

2. Life history and reproductive success—predictor of rate of spread and time to impact

a. Adult longevity

b. Adult biting rate

c. Mating efficiency

d. Egg clutch size and hatching rate

e. Sex ratio of progeny

f. Development and mortality rate at different life stages

3. Construct functionality—predictor of entomological and epidemiological efficacy

a. Population suppression—population decline in cages

b. Population replacement—reduction in carriage of the target parasite species

4. Functional resistance—predictor of duration of protection

a. Population suppression and replacement—functional resistance to the drive

b. Population replacement—parasite resistance to the effector(s)