. 2020 Mar 30;30(3):137–147. doi: 10.1089/cap.2019.0125

Table 2.

Effects of Baseline Anxiety/Depression Symptom Score, Dose, Dose², and Their Interaction on Methylphenidate Adverse Effect Ratings (n = 171)

								Interaction deconstruction
AE	Intercept	ANX/DEP main effect (β)	Dose main effect (β)	Dose² main effect^a(β)	Dose comparisons of AE scores	ANX/DEP × dose interaction (β)	ANX/DEP × dose² interaction^a(β)	Effect of ANX/DEP at baseline (β)	Effect of ANX/DEP on placebo (β)	Effect of ANX/DEP on high dose MPH (β)
Anxiety	0.41^b	0.06^b	−0.46^b	0.17^b	NI	−0.07^b	0.03^c	0.06^b	0.02^d	0.01^e
Sadness	0.27^b	0.06^b	−0.28^b	0.14^b	NI	−0.08^b	0.02^b	0.06^b	NS	NS
Social Withdrawal	0.11^b	0.02^b	−0.15^c	0.09^b	NI	−0.01^e		0.02^b	NS	NS
Headaches	0.26^b	0.03^b	−0.29^b	0.14^b	NI	−0.02^b		0.03^b	NS	NS
Stomachaches	0.26^b	0.03^c	−0.21^c	0.14^b	NI	−0.01^e		0.03^b	NS	NS
Tiredness	0.25^b	0.02^d	−0.23^c	0.09^d	NI	−0.01^e		0.02^e	NS	NS
Irritability	0.38^b	0.04^b	0.01		NI	−0.02^d		0.04^b	0.02^e	NS
Trouble Sleeping	0.11^b	0.01^e	−0.07	0.13^b	BL < PL < HD	−0.01		NA	NA	NA
Appetite	0.04^d	0.01^e	0.09	0.09^d	BL < PL < HD	−0.00		NA	NA	NA
Picking	0.35^b	0.02^e	−0.34^b	0.13^b	BL > PL, PL = HD, BL > HD	−0.00		NA	NA	NA

^{^a}

If the dose² main effect and/or and comorbidity × dose² interaction effect were not significant, they were not retained in the models.

^{^b}

p < 0.0001.

^{^c}

p < 0.001.

^{^d}

p < 0.01.

^{^e}

p < 0.05.

Findings from primary analyses are presented in boldface.

β, standardized beta coefficient; AE, adverse effect; ANX/DEP, anxiety/depression symptom score; BL, baseline condition; HD, high dose methylphenidate; MPH, methylphenidate; NA, not applicable due to the absence of significant interaction effects; NI, not interpretable due to higher-order significant interaction effect; NS, not significant; PL, placebo.