Table 1.
Top Upregulated and Downregulated Genes in KC-PsO1-iPSCs and KC-PsO2-iPSCs Compared with KCs Derived from Ctr-iPSCs (P < 0.05>
| Upregulated genes | |||||
|---|---|---|---|---|---|
| Gene symbol | Gene title | PsO1 vs. Ctr |
PsO2 vs. Ctr |
||
| Log2 FC | P | Log2 FC | P | ||
| IFITM1 | IFN-induced transmembrane protein 1 | 6.82 | 5.00E-05 | 3.95 | 5.00E-05 |
| IFIT3 | IFN-induced protein with tetratricopeptide repeats 3 | 6.73 | 5.00E-05 | 3.39 | 5.00E-05 |
| BST2 | Bone marrow stromal cell antigen 2 | 6.02 | 5.00E-05 | 2.02 | 5.00E-05 |
| IFIT2 | IFN-induced protein 44 | 5.92 | 5.00E-05 | 2.32 | 5.00E-05 |
| IFI44 | IFN-induced protein 44 like | 5.85 | 5.00E-05 | 2.67 | 5.00E-05 |
| IFIT1 | IFN-induced protein with tetratricopeptide repeats 1 | 5.81 | 5.00E-05 | 2.03 | 5.00E-05 |
| IFI44L | IFN-induced protein 44 like | 5.64 | 5.00E-05 | 2.92 | 5.00E-05 |
| OAS3 | 2′-5′-oligoadenylate synthetase | 5.44 | 5.00E-05 | 3.01 | 5.00E-05 |
| MX1 | MX dynamin like GTPase 1 | 5.28 | 5.00E-05 | 2.11 | 5.00E-05 |
| OAS1 | 2′-5′-oligoadenylate synthetase 1 | 5.11 | 5.00E-05 | 2.17 | 5.00E-05 |
| IFI6 | IFN alpha inducible protein 6 | 4.72 | 5.00E-05 | 1.73 | 5.00E-05 |
| IFITM2 | IFN-induced transmembrane protein 2 | 4.45 | 5.00E-05 | 2.67 | 5.00E-05 |
| IFITM3 | IFN-induced transmembrane protein 3 | 4.42 | 5.00E-05 | 3.46 | 5.00E-05 |
| ISG15 | ISG15 ubiquitin-like modifier | 4.20 | 5.00E-05 | 1.62 | 5.00E-05 |
| IFI16 | IFN gamma inducible protein 16 | 2.19 | 5.00E-05 | 1.09 | 5.00E-05 |
| IFIH1 | IFN-induced with helicase C domain 1 | 1.91 | 5.00E-05 | 0.77 | 5.00E-05 |
| IRF9 | IFN regulatory factor 9 | 1.48 | 5.00E-05 | 0.55 | 0.0036 |
| IFIT5 | IFN-induced protein with tetratricopeptide repeats 5 | 2.69 | 5.00E-05 | 1.42 | 5.00E-05 |
| CXCL14 | C-X-C motif chemokine ligand 14 | 2.54 | 5.00E-05 | 1.44 | 5.00E-05 |
| CXCL10 | C-X-C motif chemokine ligand 10 | 2.32 | 0.00035 | 1.41 | 0.00345 |
| SERPING1 | Serpin family G member 1 | 4.37 | 5.00E-05 | 1.44 | 5.00E-05 |
| SH2D5 | SH2 domain containing 5 | 3.93 | 5.00E-05 | 2.77 | 5.00E-05 |
| PARP12 | Poly (ADP-ribose) polymerase family member 12 | 3.71 | 5.00E-05 | 1.99 | 5.00E-05 |
| PARP14 | Poly (ADP-ribose) polymerase family member 14 | 2.82 | 5.00E-05 | 1.35 | 5.00E-05 |
| KRTAP19–1 | Keratin-associated protein 19–1 | 3.27 | 5.00E-05 | 3.70 | 5.00E-05 |
| GDF15 | Growth differentiation factor 15 | 3.26 | 5.00E-05 | 2.80 | 5.00E-05 |
| HSPA6 | Heat shock protein family A (Hsp70) member 6 | 2.58 | 0.0001 | 4.37 | 5.00E-05 |
| RPP25 | Ribonuclease P and MRP subunit p25 | 2.32 | 5.00E-05 | 1.24 | 0.0003 |
| HLA-C | MHC, class I, C | 1.10 | 0.0082 | 4.55 | 5.00E-05 |
| CD274 | CD274 molecule | 2.13 | 5.00E-05 | 1.24 | 5.00E-05 |
| CD55 | CD55 molecule | 1.65 | 5.00E-05 | 1.21 | 5.00E-05 |
| TNFAIP2 | TNF-alpha-induced protein 2 | 2.04 | 5.00E-05 | 1.53 | 5.00E-05 |
| TRIM21 | Tripartite motif containing 21 | 2.02 | 5.00E-05 | 0.81 | 0.00015 |
| SLC6A8 | Solute carrier family 6 member 8 | 1.74 | 5.00E-05 | 1.05 | 5.00E-05 |
| SLC25A25 | Solute carrier family 25 member 25 | 1.71 | 5.00E-05 | 1.18 | 5.00E-05 |
| SLC20A1 | Solute carrier family 20 member 1 | 1.33 | 5.00E-05 | 1.89 | 5.00E-05 |
| SLC19A2 | Solute carrier family 19 member 2 | 1.28 | 5.00E-05 | 1.27 | 5.00E-05 |
| KLF4 | Kruppel like factor 4 | 1.66 | 5.00E-05 | 0.88 | 5.00E-05 |
| PRRT4 | Proline rich transmembrane protein 4 | 1.50 | 5.00E-05 | 2.78 | 5.00E-05 |
| FOXC1 | Forkhead box C1 | 1.30 | 5.00E-05 | 3.87 | 5.00E-05 |
| S100P | S100 calcium-binding protein P | 1.15 | 5.00E-05 | 2.88 | 5.00E-05 |
| S100A14 | S100 calcium-binding protein A14 | 0.73 | 0.00015 | 0.69 | 5.00E-05 |
| DUSP10 | Dual specificity phosphatase 10 | 1.07 | 5.00E-05 | 1.19 | 5.00E-05 |
| SOCS1 | Suppressor of Cytokine Signaling 1 | 1.01 | 0.00505 | 1.30 | 0.00005 |
| NOTCH1 | Notch receptor 1 | 0.99 | 5.00E-05 | 0.61 | 5.00E-05 |
| Downregulated genes | |||||
|---|---|---|---|---|---|
| |
|
PsO1 vs. Ctr |
PsO2 vs. Ctr |
||
| Gene symbol | Gene title | Log2 FC | P | Log2 FC | P |
|
SLC38A11 |
Solute carrier family 38 member 11 |
−6.15 |
5.00E-05 |
−2.93 |
5.00E-05 |
|
SLC22A3 |
Solute carrier family 22 member 3 |
−3.29 |
5.00E-05 |
−1.18 |
5.00E-05 |
|
SLC12A8 |
Solute carrier family 12 member 8 |
−3.16 |
5.00E-05 |
−2.45 |
5.00E-05 |
|
SLC2A14 |
Solute carrier family 2 member 14 |
−1.94 |
5.00E-05 |
−2.55 |
5.00E-05 |
|
SLC6A1 |
Solute carrier family 6 member 1 |
−2.06 |
5.00E-05 |
−2.12 |
5.00E-05 |
|
SLC9A3R1 |
SLC9A3 regulator 1 |
−1.10 |
5.00E-05 |
−0.64 |
5.00E-05 |
|
UCN2 |
Urocortin 2 |
−5.02 |
0.00465 |
−1.41 |
5.00E-05 |
|
ABCA4 |
ATP-binding cassette subfamily A member 4 |
−4.75 |
5.00E-05 |
−1.78 |
5.00E-05 |
|
PAEP |
Progestagen-associated endometrial protein |
−4.74 |
0.00015 |
−0.93 |
5.00E-05 |
|
GFI1 |
Growth factor-independent 1 transcriptional repressor |
−4.66 |
5.00E-05 |
−1.21 |
5.00E-05 |
|
KLK7 |
Kallikrein-related peptidase 7 |
−4.54 |
5.00E-05 |
−1.94 |
5.00E-05 |
|
CYP26A1 |
Cytochrome P450 family 26 subfamily A member 1 |
−4.29 |
0.0043 |
−2.33 |
5.00E-05 |
|
CFTR |
Cystic fibrosis transmembrane conductance regulator |
−7.95 |
5.00E-05 |
−0.60 |
0.0001 |
|
ICOS |
Inducible T cell costimulator |
−4.25 |
5.00E-05 |
−2.71 |
5.00E-05 |
|
PRR9 |
Proline rich 9 |
−3.67 |
0.0012 |
−2.28 |
5.00E-05 |
|
PITX2 |
Paired-like homeodomain 2 |
−3.56 |
5.00E-05 |
−0.91 |
5.00E-05 |
|
COL7A1 |
Collagen type VII alpha 1 chain |
−3.51 |
5.00E-05 |
−1.50 |
5.00E-05 |
|
IL2RB |
Interleukin 2 receptor subunit beta |
−3.46 |
5.00E-05 |
−0.91 |
5.00E-05 |
|
HLA-DQA1 |
MHC, class II, DQ alpha 1 |
−3.39 |
5.00E-05 |
−1.83 |
5.00E-05 |
|
KCNF1 |
Potassium voltage-gated channel modifier subfamily F member 1 |
−3.37 |
5.00E-05 |
−2.41 |
5.00E-05 |
|
CYP24A1 |
Cytochrome P450 family 24 subfamily A member 1 |
−3.28 |
5.00E-05 |
−2.26 |
5.00E-05 |
|
S100A9 |
S100 calcium-binding protein A9 |
−3.14 |
5.00E-05 |
−1.29 |
5.00E-05 |
|
CGB8 |
Chorionic gonadotropin subunit beta 8 |
−3.07 |
0.0041 |
−2.22 |
0.00045 |
|
ANXA8 |
Annexin A8 |
−3.04 |
5.00E-05 |
−0.73 |
5.00E-05 |
|
STRA6 |
Stimulated by retinoic acid 6 |
−3.03 |
5.00E-05 |
−1.24 |
5.00E-05 |
|
IVL |
Involucrin |
−3.01 |
5.00E-05 |
−1.54 |
5.00E-05 |
|
SERPINA1 |
Serpin family A member 1 |
−2.97 |
5.00E-05 |
−1.53 |
5.00E-05 |
|
NEFL |
Neurofilament ligh |
−2.91 |
0.0002 |
−0.68 |
0.0197 |
|
PGLYRP4 |
Peptidoglycan recognition protein 4 |
−2.85 |
5.00E-05 |
−1.99 |
5.00E-05 |
|
KRT3 |
Keratin 3 |
−2.80 |
0.0003 |
−2.05 |
5.00E-05 |
|
KRT16 |
Keratin 16 |
−1.69 |
5.00E-05 |
−1.56 |
5.00E-05 |
|
CD52 |
CD52 molecule |
−2.72 |
0.046 |
−1.59 |
0.00165 |
|
NR0B1 |
Nuclear receptor subfamily 0 group B member 1 |
−2.70 |
5.00E-05 |
−1.16 |
0.0002 |
|
EBI3 |
Epstein-Barr virus induced 3 |
−2.58 |
5.00E-05 |
−0.88 |
5.00E-05 |
|
PCDHB13 |
Protocadherin beta 13 |
−2.53 |
5.00E-05 |
−1.67 |
5.00E-05 |
|
PCDHGC5 |
Protocadherin gamma subfamily C, 5 |
−1.21437 |
0.03365 |
−1.0337 |
0.03975 |
|
EDN1 |
Endothelin 1 |
−2.51 |
5.00E-05 |
−0.70 |
0.00025 |
|
SPRR3 |
Small proline rich protein 3 |
−2.48 |
5.00E-05 |
−1.29 |
5.00E-05 |
|
PLA2G2F |
Phospholipase A2 group IIF |
−2.39 |
5.00E-05 |
−0.89 |
0.0002 |
|
GJB4 |
Gap junction protein beta 4 |
−2.35 |
5.00E-05 |
−2.08 |
5.00E-05 |
|
BST1 |
Bone marrow stromal cell antigen 1 |
−2.32 |
5.00E-05 |
−1.96 |
5.00E-05 |
|
C2orf54 |
Mab-21 like 4 |
−2.14 |
5.00E-05 |
−1.99 |
5.00E-05 |
|
CRCT1 |
Cysteine rich C-terminal 1 |
−2.13 |
5.00E-05 |
−2.19 |
5.00E-05 |
|
UCP2 |
Uncoupling protein 2 |
−1.81 |
5.00E-05 |
−1.54 |
5.00E-05 |
|
UCHL1 |
Ubiquitin C-terminal hydrolase L1 |
−1.75 |
5.00E-05 |
−1.90 |
5.00E-05 |
|
RWDD2B |
RWD domain containing 2B |
−1.72 |
5.00E-05 |
−1.95 |
5.00E-05 |
|
GPR78 |
G protein-coupled receptor 78 |
−1.67 |
0.0002 |
−1.96 |
5.00E-05 |
|
DSG1 |
Desmoglein 1 |
−1.63 |
5.00E-05 |
−1.56 |
5.00E-05 |
|
PROM2 |
Prominin 2 |
−1.57 |
5.00E-05 |
−1.50 |
5.00E-05 |
|
CYSRT1 |
Cysteine rich tail 1 |
−1.35 |
0.00105 |
−1.90 |
5.00E-05 |
| PAMR1 | Peptidase domain containing associated with muscle regeneration 1 | −1.29 | 5.00E-05 | −1.96 | 5.00E-05 |
FC, fold change; IFN, interferon; iPSC, induced pluripotent stem cell; KC, keratinocyte; MHC, major histocompatibility complex.