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. 2020 Mar 16;9(1):132–141. doi: 10.1080/21623945.2020.1738792

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The schematic diagram of the involvement of Ca²⁺-permeable ion channels in adipogenesis

In pre-adipocytes or bone marrow mesenchymal stem cells (BMSCs), several different types of Ca²⁺-permeable ion channels, such as Ca²⁺ release-activated Ca²⁺ (CRAC) channels, transient receptor potential (TRP) channels, voltage-gated calcium (Cav) channels and other channels, are expressed and contributed in adipogenesis. Upon these channels activation by respective stimuli, extracellular Ca²⁺ entry into the cytoplasm. And the increase of cytosolic Ca²⁺ modulates adipogenesis by promoting transcription via different mechanisms. PPARγ: peroxisome proliferator-activated receptor γ; C/EBPα: CCAAT-enhancer-binding protein α.