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. Author manuscript; available in PMC: 2020 Jul 10.
Published in final edited form as: Cell Host Microbe. 2019 Jun 25;26(1):86–99.e7. doi: 10.1016/j.chom.2019.05.008

Figure 1. Approach for discovery and functional validation of host-pathogen interactions.

Figure 1.

(A) Schematic of Vif recruitment of CBFß to the CUL5 E3 ligase complex for ubiquitination and degradation of APOBEC3G.

(B) Schematic of the approach for discovering host-pathogen interactions using quantitative proteomics and functional validating the interactions by CRISPR-Cas9 based KO in primary cells.