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. Author manuscript; available in PMC: 2020 Apr 13.
Published in final edited form as: Sci Transl Med. 2015 Nov 18;7(314):314ra184. doi: 10.1126/scitranslmed.aad1904

Fig. 3. Reducing Idol expression attenuates the deposition of fibrillar amyloid.

Fig. 3.

(A) Representative micrographs showing thioflavin S staining of brain sections from APP/PS1;Idol+/+, APP/PS1;Idol+/−, or APP/PS1;Idol−/− mice. White color indicates thioflavin S fluorescence. Scale bar, 250 μm. (B) Quantification of thioflavin S (ThioS)–stained Aβ plaque load in the frontal cortex and hippocampus of male or female APP/PS1;Idol+/+, APP/PS1;Idol+/−, or APP/PS1;Idol−/− mice. Error bars represent SEM. *P < 0.05, **P < 0.01 by Student’s t test. n = 6.