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. Author manuscript; available in PMC: 2020 Sep 12.
Published in final edited form as: Nat Biomed Eng. 2020 Mar 12;4(3):286–297. doi: 10.1038/s41551-020-0527-8

Figure 4. Short- and long-term longitudinal RSOM imaging of Padeliporfin VTP effects in CT26 tumours.

Figure 4.

a, RSOM MIP images of a CT26 tumour after Padeliporfin VTP over time. Arrows indicate the destruction of representative vessels and haemorrhage after 60 min. Scale bar = 2 mm. b, Quantitative analysis of VTP effect. Relative amount of haemoglobin and the number of vessel fragments were quantified in each frequency channel over time. n = 3, biological replicates. Mean ± SD. c, Photographs of a BalbC mouse with CT26 tumour in the right thigh over time up to 5 days after VTP treatment. Dark tissue reflects necrosis. Dotted circle = tumour area. d, RSOM MIP images of the vascular network of a CT26 tumour over time up to 5 days after Padeliporfin VTP. Arrows follow individual vessels over time. Scale bar = 2 mm. e, Quantitative analysis of the relative vascular area (total signal), relative number of vessel fragments, and relative haemoglobin signal in the red (larger vessels) and green (smaller) channels in CT26 tumours after VTP over time. n = 3, biological replicates. Mean ± SD.