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N-glycan profile determined based on HILIC-HPLC analysis after labeling with 2-AB.
| N-glycan type | mAb glycovariant |
|||
|---|---|---|---|---|
| G0 F | G2 F | ST3 | ST6 | |
| G0 F | 82.1 | 0.2 | 0.4 | 0.4 |
| G1 F | 1.6 | 0.4 | 0.2 | 0.2 |
| G2 F | 0.1 | 81.1 | 1.1 | 1.8 |
| G2S1 F | 0.1 | 0.4 | 16.9 | 17.9 |
| G2S2 F | 0.3 | 0.5 | 58.0 | 54.1 |
| G0 F-N | 1.9 | – | 0.1 | 0.1 |
| G1 F-N | – | 1.8 | 0.4 | 0.5 |
| G1S1 F-N | – | – | 2.5 | 2.5 |
| Afucosylated | 6.5 | 6.7 | 6.7 | 6.3 |
| M5 | 3.1 | 3.7 | 6.3 | 6.5 |
| Minor | 4.3 | 5.2 | 7.5 | 9.7 |
*Afucosylated type as a sum of G0, G1, G2, G0-N, G1-N, G2S1 and G2S2
