Table 3.
Potentiation of Novobiocin Activity by Top Hits in Efflux-proficient (WT-Pore) and –deficient (ΔTolC) Cells
| NOV MIC (mg/L) in the presence of compounds at a given concentration (μM) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WT-Pore | ΔTolC | |||||||||
| compound | 0 | 6.25 | 12.5 | 25 | 50 | 0 | 6.25 | 12.5 | 25 | 50 |
| 24123034 | 32 | 32 | 16 | 8 | 4 | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 |
| 36287038 | 32 | 32 | 32 | 32 | 16 | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 |
| 56871955 | 32 | 32 | 32 | 16 | 8 | 0.5 | 0.5 | 0.5 | 0.25 | 0.25 |
| 58997260 | 32 | 32 | 32 | 16 | 8 | 0.5 | 0.5 | 0.25 | 0.25 | 0.125 |
| 65071797 | 32 | 32 | 32 | 4 | 4 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| 98577577 | 32 | 32 | 32 | 32 | 4 | 0.5 | 0.5 | 0.5 | 0.25 | 0.5 |