Table 2. Effects of amino acid substitution on urate uptake by URAT1 (pmol/oocyte/hour).

SNP ID	Amino acid change	Mean	SE	P	Significance
Wildtype	No Change	8.202	0.412	1.00
rs930110938	p.Leu98Phe	8.275	0.205	0.88
rs552232030	p.Ala209Val	0.215	0.073	0.00	a
rs145738825	p.Ala226Val	5.659	0.181	0.00	a
rs201136391	p.Ala227Thr	3.830	0.291	0.00	a
chr11:64366046	p.Gln297Ter	0.115	0.058	0.00	a
chr11:64366080	p.Lys308Arg	8.960	0.469	0.24
chr11:64368218	p.Val469Ala	8.720	0.654	0.51
rs1382724038	p.Gln533Lys	7.898	0.298	0.56
chr11:64368979	p.His540Tyr	0.175	0.039	0.00	a
Negative control	Water	0.075	0.027	0.00	a

Amino acid changes are based on ENST00000377574.

^aUrate uptake is significantly lower than wildtype.