Table 2. MIC determinations for ONC201, ONC212, and ADEP1 against a panel of non-ESKAPE bacteria or mycobacteria.
| Compound | N. gonorrhoeae (WHOY) | N. gonorrhoeae (ATCC 49226) | M. smegmatis (mc2155) | M. tuberculosis (H37Ra) | E. coli (BW25113) | E. coli (∆tolC∆bamB) |
|---|---|---|---|---|---|---|
| ONC201 (μM) | 250–500 | 125–250 | 125–250 | 250–500 | > 500 | > 250 |
| ONC212 (μM) | 31.25–62.5 | 31.25–62.5 | > 250 | > 100 | > 250 | 50–100 |
| ADEP1 (μM) | — | — | > 360 | — | — | — |
Strains are indicated in parentheses for each species. Dashes indicate not tested. ATCC, American Type Culture Collection.