Table 2:
Comparison of individuals with early-onset CRC vs. late-onset CRC
| Variable, n (%) | Early-onset (n=269) | Late-onset (n=2802) | Univariable Pa | Multivariable OR (95% CI) | Multivariable P | |
|---|---|---|---|---|---|---|
| Sociodemographic | Age at CRC diagnosis, mean (SD) | 43 (6) | 71 (11) | |||
| Male sex | 146 (54) | 1335 (48) | .04 | 1.44 (1.11 – 1.87) | <.01 | |
| Race/Ethnicity | <.01 | |||||
| Non-Hispanic White | 154 (57) | 1970 (70) | ||||
| Non-Hispanic Black | 26 (10) | 219 (8) | 1.73 (1.08 – 2.65) | .02 | ||
| Non-Hispanic Asian | 24 (9) | 126 (5) | 2.60 (1.57 – 4.15) | <.01 | ||
| Hispanic | 10 (4) | 88 (3) | 1.64 (.78 – 3.09) | .16 | ||
| Other | 55 (20) | 399 (14) | 1.89 (1.34 –2.65) | <.01 | ||
| Income, mean (SD) | 72325 (27127) | 72307 (26135) | .99 | |||
| High school education, %, mean (SD) | 85 (9) | 86 (9) | .38 | |||
| Medical | BMI, mean (SD) | 27 (6) | 28 (6) | .02 | .98 (.95 – .99) | .04 |
| Family history of CRC | 34 (13) | 148 (5) | <.01 | 2.87 (1.89 – 4.25) | <.01 | |
| Inflammatory bowel disease | 7 (3) | 27 (1) | .03 | 2.97 (1.16 – 6.63) | .01 | |
| Crohns disease | 4 (57) | 21 (78) | ||||
| Ulcerative colitis | 3 (43) | 6 (22) | ||||
| Duration of IBD prior to CRC diagnosis, y, median (IQR) | 22 (17–25) | 13 (0–36) | .71 | |||
Abbreviations: CRC, colorectal cancer; BMI, body mass index
a
Chi-squared and Fisher exact tests were used for categorical variables and Student’s t-test and Mann-Whitney U test for continuous variables.