Table 5.
The association of gender with PsA life impact and disease activity over time among 458 psoriatic arthritis patients.
Model covariates | Logistic regression Outcome PsAID≥4, OR (95% CI), p-value | Linear regression Outcome PsAID Beta coefficient (95% CI), p-value | ||
---|---|---|---|---|
Simple models adjusted for age and PsA duration | ||||
Gender | 2.71 (1.85, 3.97) | <0.001 | 1.37 (0.94, 1.79) | <0.001 |
Follow-up time (months) | 0.96 (0.88, 1.04) | 0.306 | −0.01 (−0.09, 0.07) | 0.769 |
Follow-up time × Gender* | 0.91 (0.81, 1.02) | 0.095 | −0.18 (−0.29, −0.06) | 0.003 |
Multivariable models adjusted for age and PsA duration | ||||
Gender* | 2.3 (1.49, 3.55) | <0.001 | 0.99 (0.60, 1.38) | <0.001 |
Follow-up time (months) | 0.93 (0.85, 1.03) | 0.170 | −0.02 (−0.10, 0.05) | 0.598 |
Follow-up time × Gender | 0.94 (0.82, 1.07) | 0.335 | −0.12 (−0.23, −0.02) | 0.023 |
Comorbidity | 1.22 (1.07, 1.39) | 0.002 | 0.18 (0.08, 0.28) | 0.001 |
TJC68 | 1.10 (1.06, 1.14) | < 0.001 | 0.08 (0.06, 0.10) | < 0.001 |
SJC66 | 1.02 (0.98, 1.07) | 0.399 | 0.02 (−0.01, 0.06) | 0.125 |
LEI | 1.34 (1.14, 1.57) | < 0.001 | 0.37 (0.24, 0.50) | < 0.001 |
Psoriasis BSA >5% | 0.99 (0.96, 1.02) | 0.567 | 0.00 (−0.03, 0.03) | 0.949 |
CRP (mg/dL) | 1.04 (0.26, 1.75) | 0.891 | 0.45 (−0.01, 0.91) | 0.054 |
Current bDMARD | 1.23 (0.87, 1.75) | 0.244 | −0.06 (−0.36, 0.25) | 0.722 |
Notations:
interaction term between follow-up time in weeks and gender. Bold font designates significant p-values. Abbreviations: TJC68 tender joint count range 0–68, SJC66 swollen joint count range 0–66, LEI Leeds enthesitis index range 0–6, VAS visual analog scale range 0–10, HAQ-DI Health Assessment Questionnaire Disability index range 0–3, BSA body surface area range 0–100%, bDMARD biologic Disease Modifying Rheumatic Drug.
Missing values for (women, men): TJC68 (0,2), SJC66 (0,2), Pain VAS (1,1), Patient global VAS (1,2)