Table 6.
< 18 weeks | 18–25 weeks | > 25 weeks | Birth | 4–7 months | 8–11 months | 12–17 months | 18–23 months | 24–35 months | |
---|---|---|---|---|---|---|---|---|---|
Maternal/family characteristics | |||||||||
Family sociodemographic factors | Q, EHR | EHR | Q | Q | Q | Q | Q | ||
Gestational hypertension, preeclampsia and gestational diabetes | Q, EHR | Q, EHR | EHR | Q | Q | ||||
Current pregnancy information, including morning sickness and vitamin/medication use | Q | Q | Q | ||||||
Maternal stress, depression, or anxiety | Q | Q | Q | Q | Q | Q | |||
Adverse events during pregnancy | EHR | EHR | EHR | Q | |||||
Reproductive history | Q, EHR | EHR | EHR | ||||||
General health and health history | Q, EHR | Q, EHR | Q, EHR | Q | Q | ||||
Sleep | Q | Q | Q | ||||||
Physical activity | Q | Q | Q | Q | |||||
Maternal substance use | Q | Q | Q | Q | Q | Q | Q | Q | |
Housing characteristics | Q | Q | Q | Q | |||||
Home environment | Q | ||||||||
Pets and pests | Q | Q | Q | Q | Q | Q | Q | ||
Maternal social support, exposure to domestic violence | Q | Q | Q | ||||||
Diet | Q | ||||||||
Labor and delivery of previous birth, and previous pregnancies | Q, EHR | Q, EHR | |||||||
Maternity leave/employment | Q | Q | Q | Q | |||||
Childcare | Q | Q | Q | Q | |||||
Food insecurity | Q | Q | |||||||
Parenting and family cohesion | Q | ||||||||
Child characteristics | |||||||||
Diet and feeding | Q | Q | Q | Q | |||||
General health, medications, and hospitalizations | Q, EHR | Q, EHR | Q, EHR | Q, EHR | Q, EHR | ||||
Early development | Q | Q | Q | Q | Q | ||||
Language development | Q | ||||||||
Emotional and behavioral development | Q | Q | |||||||
Floor time and devices that hold the baby | Q | Q | Q | ||||||
Media exposure | Q | Q | Q | Q | Q | ||||
Sleep | Q | Q | Q | Q | |||||
Clinical measures | |||||||||
Fetal sonographic measurements | Measured | Measured | Measured | ||||||
Brachial artery distensibility, blood pressure | M:Measured |
M:Measured C:Measured |
|||||||
Weight and height |
M:Q, EHR P:Q |
M:EHR | M:EHR |
M:Q, EHR C:Q, EHR |
C:Q | C:Q | C:Q |
M:Measured C:Measured |
M:Measured C:Measured |
Anogenital distance | Measured | Measured | Measured | ||||||
Fat, lean mass (DXA scan) | C:Measured | C:Measured | |||||||
Biological measures | |||||||||
Bisphenols, phthalate metabolites, dialkylphosphate metabolites, polycyclic aromatic hydrocarbon metabolites | M:Urine | M:Urine | M:Urine | C:Urine | C:Urine | ||||
Biomarkers of oxidant stress | M:Urine | M:Urine | M:Urine | C:Urine | C:Urine | ||||
Metabolomics | M:Urine | M:Urine | M:Urine | C:Urine | C:Urine | ||||
Adiponectin and leptin | Cord serum | ||||||||
Thyroid function and Thyroid peroxidase antibody | M:Serum | ||||||||
Biomarkers of inflammation and endothelial dysfunction | M:Serum | M:Serum | M:Serum | Cord serum | |||||
Sex steroids | M:Serum | ||||||||
Methylomics (genome-wide) | Cord PAXgene | ||||||||
Transcriptomics (genome-wide) | Cord PAXgene |
Q questionnaire as completed by mothers, EHR electronic health record, C child, M maternal, P partner