Table 6.
Variables measured in NYU CHES through child age 2 years
| < 18 weeks | 18–25 weeks | > 25 weeks | Birth | 4–7 months | 8–11 months | 12–17 months | 18–23 months | 24–35 months | |
|---|---|---|---|---|---|---|---|---|---|
| Maternal/family characteristics | |||||||||
| Family sociodemographic factors | Q, EHR | EHR | Q | Q | Q | Q | Q | ||
| Gestational hypertension, preeclampsia and gestational diabetes | Q, EHR | Q, EHR | EHR | Q | Q | ||||
| Current pregnancy information, including morning sickness and vitamin/medication use | Q | Q | Q | ||||||
| Maternal stress, depression, or anxiety | Q | Q | Q | Q | Q | Q | |||
| Adverse events during pregnancy | EHR | EHR | EHR | Q | |||||
| Reproductive history | Q, EHR | EHR | EHR | ||||||
| General health and health history | Q, EHR | Q, EHR | Q, EHR | Q | Q | ||||
| Sleep | Q | Q | Q | ||||||
| Physical activity | Q | Q | Q | Q | |||||
| Maternal substance use | Q | Q | Q | Q | Q | Q | Q | Q | |
| Housing characteristics | Q | Q | Q | Q | |||||
| Home environment | Q | ||||||||
| Pets and pests | Q | Q | Q | Q | Q | Q | Q | ||
| Maternal social support, exposure to domestic violence | Q | Q | Q | ||||||
| Diet | Q | ||||||||
| Labor and delivery of previous birth, and previous pregnancies | Q, EHR | Q, EHR | |||||||
| Maternity leave/employment | Q | Q | Q | Q | |||||
| Childcare | Q | Q | Q | Q | |||||
| Food insecurity | Q | Q | |||||||
| Parenting and family cohesion | Q | ||||||||
| Child characteristics | |||||||||
| Diet and feeding | Q | Q | Q | Q | |||||
| General health, medications, and hospitalizations | Q, EHR | Q, EHR | Q, EHR | Q, EHR | Q, EHR | ||||
| Early development | Q | Q | Q | Q | Q | ||||
| Language development | Q | ||||||||
| Emotional and behavioral development | Q | Q | |||||||
| Floor time and devices that hold the baby | Q | Q | Q | ||||||
| Media exposure | Q | Q | Q | Q | Q | ||||
| Sleep | Q | Q | Q | Q | |||||
| Clinical measures | |||||||||
| Fetal sonographic measurements | Measured | Measured | Measured | ||||||
| Brachial artery distensibility, blood pressure | M:Measured |
M:Measured C:Measured |
|||||||
| Weight and height |
M:Q, EHR P:Q |
M:EHR | M:EHR |
M:Q, EHR C:Q, EHR |
C:Q | C:Q | C:Q |
M:Measured C:Measured |
M:Measured C:Measured |
| Anogenital distance | Measured | Measured | Measured | ||||||
| Fat, lean mass (DXA scan) | C:Measured | C:Measured | |||||||
| Biological measures | |||||||||
| Bisphenols, phthalate metabolites, dialkylphosphate metabolites, polycyclic aromatic hydrocarbon metabolites | M:Urine | M:Urine | M:Urine | C:Urine | C:Urine | ||||
| Biomarkers of oxidant stress | M:Urine | M:Urine | M:Urine | C:Urine | C:Urine | ||||
| Metabolomics | M:Urine | M:Urine | M:Urine | C:Urine | C:Urine | ||||
| Adiponectin and leptin | Cord serum | ||||||||
| Thyroid function and Thyroid peroxidase antibody | M:Serum | ||||||||
| Biomarkers of inflammation and endothelial dysfunction | M:Serum | M:Serum | M:Serum | Cord serum | |||||
| Sex steroids | M:Serum | ||||||||
| Methylomics (genome-wide) | Cord PAXgene | ||||||||
| Transcriptomics (genome-wide) | Cord PAXgene | ||||||||
Q questionnaire as completed by mothers, EHR electronic health record, C child, M maternal, P partner