TABLE 2.
Activation of stem cells by neurogenic stimuli in the adult, aged and pathological SVZ.
| System (SVZ) | Neurogenic stimulus | Activation of SVZ stem cells (Ki67/BrdU+GFAP or nestin/Sox2+) | Activation of SVZ neuroblasts/neurons (Ki67/Brdu+ and/or DCX+ or NeuN+) | Cognitive effects | References |
| Adult | Running | NO | YES (DCX+ or BrdU/Ki67+) (prolonged) | – | Bednarczyk et al., 2009; Nicolis di Robilant et al., 2019 |
| Swimming | – | YES (BrdU+ and DCX+) | – | Chae et al., 2014 | |
| Fluoxetine | NO | NO | – | Ohira and Miyakawa, 2011; Nasrallah et al., 2010; Kodama et al., 2004 | |
| Nutrient: Astragaloside VI (after ischemia) | YES | – | – | Chen et al., 2019 | |
| Adult (after corticosterone-induced depression-like state) | Fluoxetine | – | YES | Rescue of depression-like state and of olfactory acuity | Siopi et al., 2016 |
| Adult (mild stress-depressed mice) | Treadmill | – | YES | Improves olfactory discrimination | Tian et al., 2020 |
| Adult (depressed by forced swim) | Fluoxetine | YES (neurospheres) | – | – | Hitoshi et al., 2007 |
| Aged | Running | YES (neurospheres) | YES (Brdu+ cells) | – | Blackmore et al., 2009 |