Table 1.
Chemical structure, MICs and IC50 of C109 and of selected derivatives.
| Molecule | Chemical structure | MIC (μg/ml) | Inhibition of Bc FtsZ* | ||||
|---|---|---|---|---|---|---|---|
| B. cenocepacia J2315 | E. coli 25922 | S. aureus 25923 | P. aeruginosa PAO1 | At 100 μM | IC50 (μM) | ||
| C109 |  |
8 | 8 | 4 | 128 | Yes | 8 |
| 10026149 |  |
32 | 16 | 2 | 16 | Yes | 20 |
| 10126130 |  |
>128 | 512 | 32 | >128 | Yes | 10 |
| 10226047 |  |
>512 | >512 | >512 | >128 | No | - |
| 10626056 |  |
>64 | >512 | 8 | >128 | Yes | 52 |
| 10726015 |  |
>64 | >512 | 512 | >128 | No | - |
| 11026176 |  |
>512 | >512 | 4 | >128 | Yes | 17 |
| 11026177 |  |
>512 | >512 | 4 | 64 | Yes | 19 |
| 11126009 |  |
>128 | >512 | 8 | >128 | Yes | 4 |
| 11126010 |  |
>128 | >512 | 4 | >128 | Yes | 15 |
| 11126015 |  |
>128 | >512 | 32 | >128 | Yes | 36 |
| 11426142 |  |
32 | 8 | 4 | 32 | Yes | 21 |
| 11426177 |  |
>128 | >512 | 256 | ND | No | – |
| 11626109 |  |
512 | >512 | >512 | ND | No | – |
| 11726041 |  |
>256 | >512 | >256 | ND | No | – |
| 11726042 |  |
>256 | >512 | >256 | ND | No | – |
| 11726256 |  |
128 | 128 | 8 | >256 | No | – |
| 11726257 |  |
16 | 8 | 8 | 128 | Yes | 3 |
| 11726258 |  |
256 | >256 | 256 | >256 | Yes | 15 |
| 11826109 |  |
256 | 128 | 16 | >256 | Yes | 30 |
| 11826110 |  |
16 | 32 | 32 | >256 | No | – |
| 11826363 |  |
16 | 16 | 64 | 256 | Yes | 30 |
| 11926141 |  |
>256 | >256 | 32 | >256 | Yes | 100 |
| 11926142 |  |
>256 | >256 | 32 | >256 | Yes | 100 |
ND, Values Not Detected because of the resistance detected in the other bacteria. * Burkholderia cenocepacia purified FtsZ protein.