Table 3.
List of side-effects grouped by grade.
| Grade 1-2 | Grade 3-4 | All grade | |
|---|---|---|---|
| no. (%) | no. (%) | no. (%) | |
| Haematological side-effects | |||
| Anaemia | 16 (80.0) | 4 (20.0) | 20 (100) |
| Neutropoenia | 40 (87.0) | 6 (13.0) | 46 (100) |
| Thrombocytopoenia | 34 (97.1) | 1 (2.9) | 35 (100) |
| Non-haematological side-effects | |||
| Abdominal pain | 45 (91.8) | 4 (8.2) | 49 (100) |
| Alkaline phosphatase | 9 (90.0) | 1 (10.0) | 10 (100) |
| Alopoecia | 7 (100) | 0 | 7 (100) |
| Anorexia | 34 (94.4) | 2 (5.6) | 36 (100) |
| AST/ALT increase | 124 (83.8) | 24 (16.2) | 148 (100) |
| Asthenia | 30 (81.1) | 7 (18.9) | 37 (100) |
| Blood bilirubin increase | 29 (93.5) | 2 (6.5) | 31 (100) |
| Confusion | 0 | 1 (100) | 1 (100) |
| Constipation | 8 (100) | 0 | 8 (100) |
| Dehydration | 0 | 1 (100) | 1 (100) |
| Diarrhoea | 114 (89.8) | 13 (10.2) | 127 (100) |
| Dizziness | 7 (100) | 0 | 7 (100) |
| Oedema | 9 (100) | 0 | 9 (100) |
| Erythema | 5 (100) | 0 | 5 (100) |
| Fatigue | 103 (89.6) | 12 (10.4) | 115 (100) |
| Fever | 7 (100) | 0 | 7 (100) |
| H&F syndrome | 34 (94.4) | 2 (5.6) | 36 (100) |
| Hair depigmentation | 11 (100) | 0 | 11 (100) |
| Headache | 17 (100) | 0 | 17 (100) |
| Hepatotoxicity | 8 (53.3) | 7 (46.7) | 15 (100) |
| High GGT | 5 (100) | 0 | 5 (100) |
| High LDH | 7 (100) | 0 | 7 (100) |
| Hyperglycaemia | 15 (83.3) | 3 (16.7) | 18 (100) |
| Hypertension | 79 (68.7) | 36 (31.3) | 115 (100) |
| Hypertriglyceridaemia | 0 | 1 (100) | 1 (100) |
| Hypocalcaemia | 7 (100) | 0 | 7 (100) |
| Hypokalaemia | 1 (50) | 1 (50) | 2 (100) |
| Hypomagnesaemia | 9 (100) | 0 | 9 (100) |
| Hypophosphataemia | 5 (100) | 0 | 5 (100) |
| Hyporexia | 7 (87.5) | 1 (12.5) | 8 (100) |
| INR increase | 7 (100) | 0 | 7 (100) |
| Insomnia | 5 (100) | 0 | 5 (100) |
| Mucositis | 37 (100) | 0 | 37 (100) |
| Nausea | 123 (96.1) | 5 (3.9) | 128 (100) |
| Pain | 19 (90.5) | 2 (9.5) | 21 (100) |
| Pancreatitis | 0 | 1 | 1 (100) |
| Proteinuria | 7 (63.6) | 4 (36.4) | 11 (100) |
| Pruritus | 4 (100) | 0 | 0 (100) |
| Rash | 18 (94.7) | 1 (5.3) | 19 (100) |
| Skin and subcutaneous tissue disorders | 6 (100) | 0 | 6 (100) |
| Skin hypopigmentation | 7 (100) | 0 | 7 (100) |
| Drowsiness | 6 (100) | 0 | 6 (100) |
| Thromboembolic events | 0 | 1 (100) | 1 (100) |
| Urinary tract infection | 0 | 1 (100) | 1 (100) |
| Vomiting | 41 (9.1) | 4 (8.9) | 45 (100) |