Table 3.

Mean differences (MD) for U46619-induced contractions after application of NSC23766 (100 µM), EHT1864 (100 µM), or dimethylsulfoxide (DMSO) or water as controls, shown for each applied U46619 concentration and with 95% confidence intervals (CI) (in square brackets, low to high) (% of KCl-induced contractions). Differences in contraction at given agonist concentrations were calculated for each single experiment (i.e., between inhibitor and control group, for corresponding, paired samples from the same bladder in each single experiment, and are expressed as MD with 95% CI. Data are based on experiments on series with n=5 female and n=7 male bladders for NSC23766, and n=5 female and n=5 male bladders for EHT1864 (experiments, where curve fitting was not possible and resulted in unpaired values, were excluded, what concerns one experiment with female bladder and EHT1864).

		U46619 concentration
		0.1 µM	0.3 µM	1 µM	3 µM	10 µM	30 µM
NSC23766	female	−1.7 [−11.9 to 8.4]	−2.1 [−13.2 to 9.1]	−2.3 [−14.6 to 10.0]	−4.6 [−16.7 to 7.5]	−2.5 [−15.8 to 10.7]	−3.6 [−16.0 to 8.7]
	male	3.5 [−9.8 to 16.8]	3.4 [−10.1 to 16.8]	0.0 [−11.8 to 11.7]	4.1 [−5.4 to 13.7]	0.7 [−11.1 to 12.6]	−0.4 [−12.8 to 12.0]
EHT1864	female	−7.4 [−13.9 to −0.9]	−8.4 [−19.0 to 2.2]	−10.1 [−19.3 to −0.9]	−10.4 [−21.7 to 1.0]	−9.2 [−23.5 to 5.1]	−11.2 [−30.6 to 8.1]
	male	−7.2 [−20.4 to 6.0]	−8.6 [−23.9 to 6.8]	−9.7 [−25.3 to 5.9]	−7.8 [−20.8 to 5.1]	−6.5 [−19.1 to 6.1]	−8.6 [−16.9 to −0.3]