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. 2020 Apr 7;8:292. doi: 10.3389/fbioe.2020.00292

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Copyright © 2020 Bloise, Rountree, Polucha, Montagna, Visai, Coulombe and Munarin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Soft and biodegradable alginate hydrogels are produced by internal crosslinking with calcium carbonate. (A) Images of AC2.5, AC5, and AC10 hydrogels, scale bar = 5 mm. (B) Wet weight variation (swelling) of hydrogels compared to their initial weight at day 0. (C) Dry weight variation (mass loss) of hydrogels compared to the initial dry weight at day 0. (D) Rheological characterization of storage (G′) and loss (G″) moduli of AC5 and AC10 by frequency sweep test at 0.5% strain and T = 23°C and (E) shear rate dependence of shear stress (filled circles) and viscosity (open triangles) at T = 23°C.