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. 2020 Apr 7;10:380. doi: 10.3389/fonc.2020.00380

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Copyright © 2020 Yang, Jiang, Yao, Wang, Sun, Qin and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transmission electron microscopy analysis of colorectal cell lines in the presence and absence of senescent fibroblasts. (A–C) Structural characteristics of the LoVo cells that co-cultured with LV-GALC fibroblasts and (D–F) LoVo cells that co-cultured with LV-NC fibroblasts. Nuclear membrane (white arrow), mitochondria (purple arrow), visible increase in rough endoplasmic reticulum ribosomes (blue arrow), tight connection between cells (red arrow), microfilament (yellow), and microtube (green).