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. 2020 Apr 7;10:466. doi: 10.3389/fonc.2020.00466

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Copyright © 2020 Cao, Liu, Chen, Yang, Huang, Song and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The concordance of mutation between ctDNA and the corresponding tumor tissues from CRC. (A) Wenn diagram shows the number and percentage of overlapped and unique mutations between the tissue DNA and the corresponding blood ctDNA samples. (B) Mutation spectrum of baseline plasma and the corresponding tumor tissues from 35 subjects. (C) The mutation concordance ratio for different stages between blood ctDNA samples and tumor tissue samples from 28 patients. (D) Comparison of tumor mutation burden (TMB) in low consistency (<75%) and high consistency (>75%) groups.