TABLE 2.

Natural-based nanoformulations and their implications for NDs.

Component	Nano vehicle/method	Disease model	Results	References
Coenzyme Q10 6-coumarin	Trimethylated chitosan-conjugated PLGA nanoparticle	AD	↓ Senile plaques ↓ Memory impairment, ↑ bioavailability	Wang et al., 2010
HupA	lactoferrin-conjugated N-trimethylated chitosan nanoparticles (Lf-TMC NPs)	AD	Appropriate sustained-release, ↑ bioavailability, ↑ targeting ability	Meng et al., 2018
Berberine	MWCNTs coated with phospholipid and polysorbate	AD	Remanded the memory impairment and quelled AChEI activity	Lohan et al., 2017
Hesperetin	Nanocrystal	AD	Improve derecognition of memory consolidation ↑ Activity of antioxidant enzymes	Kheradmand et al., 2018
Vitamin E	PEG-based nanospheres	AD	↑ Antioxidant efficacy of vitamin E	Shea et al., 2005
Retinoic acid (RA)	PNPs	PD	Significant neuroprotective effect on dopaminergic neurons	Esteves et al., 2015
Chrysin	SLNs	AD	↑ Oral bioavailability, ↑free radical scavenging, ↓ neuronal damage	Vedagiri and Thangarajan, 2016
Sialic acid and peptide-B6	Selenium nanoparticles	AD	Disaggregated the Aβ fibrils and inhibited the Aβ aggregation	Yin et al., 2015
Cysteine	Selenium nanoparticles	AD	↓ ROS, prevented Aβ aggregation	Zhou et al., 2015
Nattokinase enzyme (NK)	PNPs	AD	Downregulate amyloid aggregation	Lohan et al., 2017