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. 2020 Apr 7;10:472. doi: 10.3389/fonc.2020.00472

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Copyright © 2020 Guo, Wang, Yan, Liu, Su, Chen, Yan, Adhikari, Wu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The biogenesis of exosomal miRNA. miRNA genes are transcribed into primary miRNA (pri-miRNA). The pri-miRNA is cleaved by Dorsha complex to produce precursor miRNA (pre-miRNA) and exported into the cytoplasma. Subsequently, pre-miRNA is processed by Dicer complex to become mature miRNA. Mature miRNA is sorted into exosomes and released to the extracellular space. With the recipient cell uptake exosomes, the miRNA entered the cell and mediates gene suppression by targeted translational repression and mRNA degradation.