Table 1.

Laboratory data

Date	Total Ca2+, mg/dL	Ionized Ca2+, mg/dL	PTH, pg/mL	PTHrP, pmol/L	Treatment
Onset of hypercalcemia (day 1)	10.6a
Day 25	12.7a	6.9c	<6.0 (nl: 18–85)	3.3e	Pamidronate 60 mg IV
Day 29	8.2#	5.2c		41.9f
Day 42		6.3d	5.8 (nl: 18.4–80.1)	Zoledronic acid 2 mg IV
Day 43	9.2#	5.6d
Day 44	8.7#
Day 47	10.1a				Denosumab 120 mg subQ
Day 50	11.1a	6.6c			Zoledronic acid 2 mg IV +
					calcitonin 200 IU subQ × 2 doses
Day 51	10.6a	6.2c
Day 53	9.6a	5.6c
Day 54	9.0a	5.4c
Day 57	10.1b
Day 58		6.0d			Cinacalcet 30 mg PO b.i.d.
Day 61	8.9a	5.5d
Day 70	9.4b	5.1d		113f
Day 76	10.1b	5.7d		Cinacalcet 60 mg PO b.i.d.
Day 82	9.4b	5.4d		194f
Day 89	8.9b	4.9d
Day 96	7.3b
Day 103	8.8b	4.9d
Day 110	8.5b	4.7d
Day 117	8.2b	4.6d		143f

Normal range key:

^a8.2–10.0;

^b8.5–10.1;

^c4.5–5.3;

^d4.6–5.4;

^e<2.0; and

^f0.0–3.4. b.i.d., administered twice daily; IU, international units; IV, intravenous; nl, normal level; PO, oral administration; subQ, subcutaneous.