Table 1.

Hb response and iron parameters in phase 2 trials

Identifier	Participants	Control	CFB of Hb	Iron parameters					Hepcidin
				CFB of ferritin	CFB of transferrin	CFB of TIBC	CFB of serum iron	CFB of TSAT
NCT01414075	Incident HD and PD	Roxa	↑	↑	NS	↑	NS	↓	↓
NCT01147666	Maintenance HD	Roxa vs. epoetin alfa	↑	↓	NS	↑	NS	NS	NS
NCT01147666	Maintenance HD	Roxa vs. epoetin alfa	NS	↓	NS	NS	NS	NS	↓
NCT00761657	Non-dialysis-dependent CKD	Roxa vs. placebo	↑	↓	NA	↑	NS	↓	↓
NCT01599507 and 01596855	Non-dialysis-dependent CKD	Roxa vs. placebo	↑	↓	↑	↑	↓	↓	↓
NCT01964196	Non-dialysis-dependent CKD	Roxa vs. placebo	↑	↓	↑	↑	NS	↓	↓
NCT01244763	Non-dialysis-dependent CKD	Roxa	↑	↓	↑	NS	↓	↓	↓

CKD, chronic kidney disease; HD, hemodialysis; NA, not available; PD, peritoneal dialysis; NS, nonsignificant; Hb, hemoglobin; CFB, change from baseline; TIBC total iron binding capacity; TSAT, transferrin saturation; Roxa, roxadustat.