Comparison 2. Oral/topical non‐absorbed prophylaxis vs. systemic antifungal prophylaxis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incidence of invasive fungal infection	3	326	Risk Ratio (M‐H, Fixed, 95% CI)	1.89 [0.66, 5.39]
2 Mortality	3	326	Risk Ratio (M‐H, Fixed, 95% CI)	1.39 [0.64, 3.00]
3 Bronchopulmonary dysplasia	1	171	Risk Ratio (M‐H, Fixed, 95% CI)	1.29 [0.67, 2.49]
4 Necrotising enterocolitis	2	267	Risk Ratio (M‐H, Fixed, 95% CI)	1.22 [0.58, 2.60]
5 Retinopathy of prematurity	1	171	Risk Ratio (M‐H, Fixed, 95% CI)	1.24 [0.51, 2.98]
6 Length of stay in NICU (days)	1	171	Mean Difference (IV, Fixed, 95% CI)	‐1.0 [‐7.63, 5.63]