Aydemir 2011b.

Methods	Randomised controlled trial
Participants	187 VLBW infants.
Interventions	Oral nystatin 100,000 U/ml 8 hourly (N = 94) versus fluconazole 3 mg/kg (N = 93) every third day versus until the 30th day after birth (or 45th day in ELBW infants)
Outcomes	Fungal colonisation and invasive infection Death prior to hospital discharge Emergence of fungi with native azole resistance Adverse drug reactions
Notes	Setting: Zekai Tahir Burak Maternity Hospital, Ankara, Turkey; 2008 to 2009 The same infants form the oral nystatin group in both Aydemir 2011a and Aydemir 2011b
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	Computer‐generated allocation
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Report states placebo‐controlled but unclear how this was achieved
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Report states placebo‐controlled but unclear how this was achieved
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Report states placebo‐controlled but unclear how this was achieved
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete follow‐up