Violaris 2010.

Methods	Randomised controlled trial
Participants	80 VLBW infants Haemodynamically unstable infants and infants with severe congenital anomalies or abnormal liver function tests were not eligible to participate
Interventions	Nystatin (100,000 units/kg/day) in each side of the mouth (N = 42) versus fluconazole (4 mg/kg) orally (N = 38) beginning on day five after birth Medications were continued until full oral feedings were attained or systemic fungal infection was diagnosed
Outcomes	Invasive fungal infection, invasive bacterial infection, biochemical indices related to liver function, mortality
Notes	Setting: Brooklyn Hospital Center, New York; 1997 to 1998
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	Computerised randomisation and allocation
Blinding (performance bias and detection bias) All outcomes	High risk	Unable to blind interventions
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unable to blind interventions
Blinding of outcome assessment (detection bias) All outcomes	High risk	Unable to blind interventions
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete follow up