Comparison 8. IL2Ra versus calcineurin inhibitor.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 at 3 months	1	51	Risk Ratio (M‐H, Random, 95% CI)	2.89 [0.12, 67.75]
1.2 at 6 months	2	103	Risk Ratio (M‐H, Random, 95% CI)	1.32 [0.14, 12.23]
1.3 at 1 year	1	54	Risk Ratio (M‐H, Random, 95% CI)	0.5 [0.05, 5.19]
2 Graft loss	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 at 6 months	2	103	Risk Ratio (M‐H, Random, 95% CI)	1.14 [0.37, 3.46]
2.2 at 1 year	1	54	Risk Ratio (M‐H, Random, 95% CI)	2.0 [0.19, 20.77]
3 Acute rejection: clinically suspected or biopsy‐proven	3	157	Risk Ratio (M‐H, Random, 95% CI)	2.26 [1.50, 3.41]
3.1 at 6 months	2	103	Risk Ratio (M‐H, Random, 95% CI)	2.15 [1.18, 3.90]
3.2 at 1 year	1	54	Risk Ratio (M‐H, Random, 95% CI)	2.37 [1.26, 4.46]
4 Acute rejection: steroid resistant	2		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
4.1 at 3 months	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4.2 at 1 year	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
5 Creatinine mg/dL	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
5.1 at 6 months	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
6 Creatinine µmol/L	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
6.1 at 6 months	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
7 Glomerular filtration rate (GFR) creatinine clearance (C‐G)	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
7.1 at 3 months	2	100	Mean Difference (IV, Random, 95% CI)	‐2.95 [‐10.93, 5.03]
7.2 at 1 year	1	51	Mean Difference (IV, Random, 95% CI)	‐17.0 [‐30.63, ‐3.37]