Daclizumab double 1999.
Methods |
|
|
Participants |
|
|
Interventions |
Treatment group
Control group
Baseline immunosuppression
|
|
Outcomes |
|
|
Notes | Pooled analysis of Daclizumab double and triple therapy studies published after primary studies. Data used only when presented separately for each study. 3 year follow‐up | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Stated "randomised, double‐blind placebo‐controlled" no further information provided |
Allocation concealment (selection bias) | Unclear risk | Not stated |
Blinding (performance bias and detection bias) Objective outcomes | Unclear risk | Double blind, blinding of outcome assessors not stated |
Blinding (performance bias and detection bias) Subjective outcomes | Unclear risk | Double blind, blinding of outcome assessors not stated |
Incomplete outcome data (attrition bias) All outcomes | Low risk | ITT analysis reported for the primary analyses of efficacy and safety, all patients followed up or accounted for |
Selective reporting (reporting bias) | Low risk | Primary outcomes for this review (death, graft loss and acute rejection) have been reported. No study protocol available to assess secondary outcomes of study |
Other bias | High risk | Not stated, but author list includes employees of Hoffmann‐LaRoche Inc |