Skip to main content
. 2010 Jan 20;2010(1):CD003897. doi: 10.1002/14651858.CD003897.pub3

Philosophe 2002.

Methods
  • RCT

Participants
  • Setting: Single centre

  • Country: USA

  • High risk for delayed graft function. First (92%) or second transplant. African‐Americans (63%)

  • Age: NS ("similar for both groups")

  • Sex: NS ("similar for both groups")

  • Number (group 1/group 2): 50 (26/24)

Interventions Treatment group 1
  • Daclizumab: 1 mg/kg day 0 and day 5


Treatment group 2
  • Muromonab‐CD3: administered for 7‐14 days


Baseline immunosuppression
  • TAC: NS

  • MMF:NS

  • Steroids: NS

Outcomes
  • Mortality

  • Graft loss

  • Acute rejection

Notes
  • 1 year follow‐up

  • On‐going study

  • Data from abstracts

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Stated "randomized", no further information provided
Allocation concealment (selection bias) Unclear risk Not stated
Blinding (performance bias and detection bias) 
 Objective outcomes Unclear risk Not stated
Blinding (performance bias and detection bias) 
 Subjective outcomes Unclear risk Not stated
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Interim results only, results presented as percentages and unsure of numbers
Selective reporting (reporting bias) Unclear risk Interim 1 year results presented
Other bias Unclear risk Funding source not stated. Abstract only data available