Comparison 10. Vaginal ring releasing etonogestrel 120 µg + EE 15 µg versus COC norgestimate 180/215/250 µg + EE 25 µg.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pregnancy per woman	1	201	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Discontinuation	2		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
2.1 Overall (84 days or 3 cycles)	2	448	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.27 [0.85, 1.88]
2.2 Overall (6 months)	1	240	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.52 [0.31, 0.88]
3 Compliance: perfect use (3 months)	1	273	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.67 [1.04, 2.68]
4 Frequent bleeding (> 4 episodes of bleeding or spotting)	1	156	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.23 [0.05, 1.03]
5 Irregular bleeding (bleeding‐free interval > 17 days)	1	156	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.77 [0.33, 1.75]
6 Prolonged bleeding (bleeding or spotting episode lasting >= 10 days)	1	156	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.42 [0.20, 0.89]
7 Satisfied or very satisfied with method	2	421	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.50 [1.01, 2.24]
8 Planned to use method	1	174	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.51 [1.32, 4.77]