Comparison 11. Vaginal ring releasing etonogestrel 120 µg + EE 15 µg versus COC levonorgestrel 150 µg + EE 30 µg.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pregnancy per woman	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.01 [0.29, 3.51]
2 Pregnancy per cycle	1	10783	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.03 [0.30, 3.55]
3 Discontinuation ‐ overall (6 or 13 cycles)	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.06 [0.81, 1.38]
4 Discontinuation ‐ adverse events (6 or 13 cycles)	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.33 [0.89, 2.00]
5 Compliance per cycle	1	10783	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.07 [0.96, 1.20]
6 Breakthrough bleeding (cycle 6)	1	770	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.22 [0.05, 0.88]
7 Breakthrough spotting (cycle 6)	1	770	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.67 [0.36, 1.24]
8 Breakthrough bleeding (cycle 13)	1	425	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.15 [0.01, 2.45]
9 Breakthrough spotting (cycle 13)	1	425	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.01 [0.38, 2.67]
10 Nausea	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.89 [0.48, 1.63]
10.1 Nausea	1	77	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.28 [0.77, 14.08]
10.2 Nausea	1	1030	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.67 [0.34, 1.31]
11 Breast tenderness or pain	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.56 [0.75, 3.23]
11.1 Breast tenderness	1	77	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.43 [0.09, 2.01]
11.2 Breast pain	1	1030	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.25 [0.99, 5.14]
12 Headache	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.30 [0.80, 2.10]
13 Dysmenorrhea	1	1030	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.86 [0.77, 4.52]
14 Abdominal pain	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.70 [0.63, 4.57]
15 Vaginitis	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.84 [1.34, 6.01]
16 Genital pruritus	1	1030	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.58 [1.14, 18.41]
17 Leukorrhea	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	6.42 [2.71, 15.22]
18 Urinary tract infection	1	1030	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.51 [0.78, 72.32]
19 Acne	1	1030	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.23 [0.08, 0.63]
20 Nervousness	1	77	Peto Odds Ratio (Peto, Fixed, 95% CI)	8.24 [0.50, 134.45]
21 Depression	1	77	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.14 [0.01, 2.32]
22 Dizziness	1	77	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.55 [0.05, 5.42]
23 Libido decrease	1	1030	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.81 [0.32, 2.05]
24 Weight increase	2	1107	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.93 [0.41, 2.13]
25 Increased glucocorticoids	1	77	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.55 [0.05, 5.42]
26 Sinusitis	1	1030	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.48 [0.15, 376.80]
27 Leg pain	1	1030	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.27 [0.65, 7.88]