Aufenacker 2004.

Methods	Study: prospective, randomised, multicenter. Allocalion: computer. Blinding: yes.
Participants	1008 patients: 505 P / 503 C
Interventions	Hernioplasty. ATB: cefuroxime 1.500 mg IV. MA: induction. Control= placebo.
Outcomes	IP= 9; IC= 8
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "A pharmacist carried out randomizations according to a computer generated list in blocks of 10 patients with stratification for each hospital."
Allocation concealment (selection bias)	Low risk	Quote: "A pharmacist prepared the trial medication under laminar airflow condition and it was packed in nontransparent material to exclude optical differences."
Blinding (performance bias and detection bias) All outcomes	Low risk	Probably yes.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Probably yes.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "In most cases, the surgeon who performed the operation did not perform the follow‐up." Comment: Probably yes.