Comparison 3. IVF versus IUI + ovarian stimulation with gonadotropins or clomiphene (CC).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Live birth rate per woman	5		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Treatment‐naive women IVF vs IUI + gonadotropins	4	745	Odds Ratio (M‐H, Fixed, 95% CI)	1.27 [0.94, 1.73]
1.2 Pretreated women IVF vs IUI + gonadotropins	1	280	Odds Ratio (M‐H, Fixed, 95% CI)	3.90 [2.32, 6.57]
1.3 Treatment‐naive women IVF vs IUI + CC	1	103	Odds Ratio (M‐H, Fixed, 95% CI)	2.51 [0.96, 6.55]
2 Clinical pregnancy rate per woman	4		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Treatment‐naive women IVF vs IUI + gonadotropins	3	627	Odds Ratio (M‐H, Fixed, 95% CI)	1.45 [1.03, 2.03]
2.2 Treatment‐naive women IVF vs IUI + CC	1	103	Odds Ratio (M‐H, Fixed, 95% CI)	4.59 [1.86, 11.35]
2.3 Pretreated women IVF vs IUI + gonadotropins	1	280	Odds Ratio (M‐H, Fixed, 95% CI)	14.13 [7.57, 26.38]
3 Multiple pregnancy rate per woman	4	848	Odds Ratio (M‐H, Fixed, 95% CI)	0.81 [0.47, 1.39]
3.1 Treatment‐naive women IUI + gonadotropins	4	745	Odds Ratio (M‐H, Fixed, 95% CI)	0.79 [0.45, 1.39]
3.2 Treatment‐naive women IVF vs IUI + CC	1	103	Odds Ratio (M‐H, Fixed, 95% CI)	1.02 [0.20, 5.31]
4 Incidence of OHSS per woman	2	324	Odds Ratio (M‐H, Fixed, 95% CI)	1.15 [0.43, 3.06]
4.1 Treatment‐naive women IVF vs IUI + gonadotropins	2	221	Odds Ratio (M‐H, Fixed, 95% CI)	1.23 [0.36, 4.14]
4.2 Treatment‐naive women IVF vs IUI + CC	1	103	Odds Ratio (M‐H, Fixed, 95% CI)	1.02 [0.20, 5.31]
5 Miscarriage rate per woman	1	206	Odds Ratio (M‐H, Fixed, 95% CI)	1.16 [0.59, 2.28]
5.1 Treatment‐naive women IVF vs IUI + CC	1	103	Odds Ratio (M‐H, Fixed, 95% CI)	1.16 [0.44, 3.02]
5.2 Treatment‐naive women IVF vs IUI+ gonadotropins	1	103	Odds Ratio (M‐H, Fixed, 95% CI)	1.16 [0.44, 3.02]