Elzeiny 2014.
| Methods | Randomised controlled parallel trial | |
| Participants | 44 couples Inclusion criteria Adults who had primary or secondary infertility ≥ 1 year in duration with evidence of ovulation and tubal patency, aged 18 to 42 years for females and 18 to 60 years for males Exclusion criteria IUI or IVF treatment in the previous 12 months, coital disorder, untreated ovulatory disorders or endometriosis (American Fertility Society criteria grades 2 to 4), tubal obstruction, abnormal semen analyses (concentration < 20 × 106/mL, progressive motility < 25%, abnormal morphology > 95% or positive sperm antibodies) or any contraindication for multiple pregnancy |
|
| Interventions | IVF vs IUI | |
| Outcomes | Live birth rate, clinical pregnancy rate, multiple pregnancy rate, OHSS, cost per live birth | |
| Notes | Financial support provided by a pharmaceutical company | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | "computer‐generated, adaptive‐biased coin randomisation schedule" |
| Allocation concealment (selection bias) | Low risk | "sequentially numbered opaque sealed envelopes" |
| Blinding (performance bias and detection bias) All outcomes | Unclear risk | This was not mentioned |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | 43/44 randomly assigned women were included in the analysis |
| Selective reporting (reporting bias) | Low risk | Study reported primary and secondary treatment outcomes adequately including adverse outcomes |
| Other bias | Low risk | No other potential bias could be observed |