Reindollar 2010.

Methods	RCT using permuted blocks of varying sizes, stratified by woman's age (< 35 vs ≥ 35 years), laparoscopy within past year (yes or no) and study site (Boston IVF or Harvard Vanguard Medical Associates). Allocation sequence was produced by random numbers generated by a congruence method. Investigators were blinded to all outcome determinations
Participants	503 couples; women 21 to 39 years of age with unexplained infertility and mild male factor of 12 months' duration
Interventions	Couples in this study were randomly assigned to conventional pathway involving clomiphene citrate plus intrauterine insemination (CC + IUI) followed by IUI + gonadotropins and then IVF; or accelerated pathway (CC + IUI followed by 6 cycles of IVF)
Outcomes	Pregnancy rate per cycle, pregnancy rate per couple, LBR per cycle, LBR per couple, time to pregnancy, charge data
Notes	Study could not be included for comparison between IVF and IUI + CC, as both arms received CC + IUI
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"The allocation sequence was produced by use of random numbers generated by a congruence method. The sequence was developed by the biostatistician and implemented by the epidemiologist"
Allocation concealment (selection bias)	Low risk	Apparently remote allocation: "The sequence was ...implemented by the epidemiologist"
Blinding (performance bias and detection bias) All outcomes	Low risk	Investigators were blinded to all outcome determinations; allocation was performed by a biostatistician and was implemented by an epidemiologist
Incomplete outcome data (attrition bias) All outcomes	Low risk	503/503 randomly assigned women analysed by intention‐to‐treat
Selective reporting (reporting bias)	Low risk	Study authors published preliminary results in 2007 and did not appear to publish or failed to publish based on results of the trial
Other bias	Low risk	No other potential biases could be detected