van Rumste 2014.

Methods	Multi‐centre RCT
Participants	116 couples with unexplained and mild male factor infertility. All couples had a standard fertility workup, including assessment of ovulation by basal temperature curve or ultrasound, a tubal patency test and sperm analysis. This study included all couples with unexplained or mild male subfertility, female age between 18 and 38 years and poor fertility prospects, defined as a 12‐month prognosis < 30% for natural conception according to the model of Hunault 2004
Interventions	1 cycle of IVF–eSET followed by 1 cryocycle or 3 cycles of IUI–ovarian stimulation. Results of freeze–thaw cycles were also included in this study, provided the transfer took place within 4 months after randomisation
Outcomes	Ongoing pregnancy rate per woman/couple, cost per cycle
Notes	Additional data on methods and outcomes were requested from lead author
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Central Internet‐based randomisation was stratified by centre
Allocation concealment (selection bias)	Unclear risk	This was not mentioned
Blinding (performance bias and detection bias) All outcomes	Unclear risk	This was not mentioned
Incomplete outcome data (attrition bias) All outcomes	Low risk	Intention‐to‐treat analysis was performed
Selective reporting (reporting bias)	Low risk	No other reports on the trial could be retrieved
Other bias	Low risk	No other potential bias was noted

Abbreviations:

AFS: American Fertility Society.

eSET: elective single embryo transfer.

FSH: follicle‐stimulating hormone.

ICSI: intracytoplasmic sperm injection.

IUI: intrauterine insemination.

IUI‐COH: intrauterine insemination‐controlled ovarian hyperstimulation.

IVF: in vitro fertilisation.

IVF‐SET: in vitro fertilisation‐single embryo transfer.

LBR: live birth rate.

SO: ovarian stimulation.