Comparison 1. Triphasic LNG 50‐75‐125 μg and EE 30‐40‐30 μg versus monophasic LNG 150 μg and EE 30 μg.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pregnancy per woman within 6 cycles	2	678	Odds Ratio (M‐H, Random, 95% CI)	0.64 [0.10, 3.91]
2 Pregnancy per woman within 12 cycles	5	4145	Odds Ratio (M‐H, Random, 95% CI)	1.35 [0.25, 7.22]
3 Proportion of cycles with spotting within 3 cycles	1	2367	Odds Ratio (M‐H, Random, 95% CI)	0.52 [0.41, 0.68]
4 Proportion of cycles with breakthrough bleeding within 3 cycles	1	2367	Odds Ratio (M‐H, Random, 95% CI)	0.48 [0.32, 0.72]
5 Proportion of cycles with spotting within 6 cycles	2	7290	Odds Ratio (M‐H, Random, 95% CI)	0.57 [0.48, 0.67]
6 Proportion of cycles with breakthrough bleeding within 6 cycles	2	7290	Odds Ratio (M‐H, Random, 95% CI)	0.63 [0.50, 0.80]
7 Proportion of cycles with spotting within 12 cycles	1	6472	Odds Ratio (M‐H, Random, 95% CI)	0.59 [0.49, 0.72]
8 Proportion of cycles with breakthrough bleeding within 12 cycles	1	6472	Odds Ratio (M‐H, Random, 95% CI)	0.59 [0.45, 0.77]
9 Proportion of women with intermenstrual bleeding within 12 cycles	1	979	Odds Ratio (M‐H, Random, 95% CI)	0.83 [0.53, 1.31]
10 Proportion of women with spotting at cycle 6	1	1032	Odds Ratio (M‐H, Random, 95% CI)	0.24 [0.03, 2.17]
11 Proportion of women with breakthrough bleeding at cycle 6	1	1032	Odds Ratio (M‐H, Random, 95% CI)	2.45 [0.47, 12.67]
12 Proportion of women with spotting at cycle 12	1	896	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.06, 16.62]
13 Proportion of women with breakthrough bleeding at cycle 12	1	896	Odds Ratio (M‐H, Random, 95% CI)	0.52 [0.05, 5.72]
14 Proportion of women with intermenstrual bleeding within 12 cycles	1	979	Odds Ratio (M‐H, Random, 95% CI)	0.83 [0.53, 1.31]
15 Proportion of women with breakthrough bleeding or spotting at cycle 3	1	314	Odds Ratio (M‐H, Random, 95% CI)	0.10 [0.01, 0.77]
16 Proportion of women with breakthrough bleeding or spotting at cycle 6	1	314	Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
17 Proportion of cycles with amenorrhea within 6 cycles	1	2777	Odds Ratio (M‐H, Random, 95% CI)	0.57 [0.28, 1.14]
18 Proportion of cycles with amenorrhea within 12 cycles	1	6472	Odds Ratio (M‐H, Random, 95% CI)	0.27 [0.17, 0.45]
19 Proportion of women with amenorrhea within 12 cycles	1	979	Odds Ratio (M‐H, Random, 95% CI)	1.47 [0.24, 8.83]
20 Total discontinuation within 6 cycles	4	1829	Odds Ratio (M‐H, Random, 95% CI)	1.04 [0.78, 1.37]
21 Discontinuation due to medical reasons within 6 cycles	3	1513	Odds Ratio (M‐H, Random, 95% CI)	1.15 [0.81, 1.61]
22 Discontinuation due to cycle disturbances within 6 cycles	1	189	Odds Ratio (M‐H, Random, 95% CI)	0.97 [0.13, 7.02]
23 Total discontinuation within 12 cycles	4	3310	Odds Ratio (M‐H, Random, 95% CI)	1.13 [0.97, 1.31]
24 Discontinuation due to medical reasons within 12 cycles	3	3010	Odds Ratio (M‐H, Random, 95% CI)	1.12 [0.71, 1.76]
25 Discontinuation due to cycle disturbances within 12 cycles	3	2109	Odds Ratio (M‐H, Random, 95% CI)	1.11 [0.56, 2.21]
26 Discontinuation due to intermenstrual bleeding within 12 cycles	1	1201	Odds Ratio (M‐H, Random, 95% CI)	1.40 [0.44, 4.44]