Comparison 4. Triphasic LNG 50‐75‐125 μg and EE 30‐40‐30 μg versus monophasic DSG 150 μg and EE 30 μg.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pregnancy per woman within 6 cycles	1	555	Odds Ratio (M‐H, Random, 95% CI)	3.0 [0.12, 73.96]
2 Pregnancy per woman within 12 cycles	2	1146	Odds Ratio (M‐H, Random, 95% CI)	7.22 [0.88, 59.00]
3 Proportion of cycles with spotting within 3 cycles	1	2763	Odds Ratio (M‐H, Random, 95% CI)	1.11 [0.88, 1.41]
4 Proportion of cycles with breakthrough bleeding within 3 cycles	1	2763	Odds Ratio (M‐H, Random, 95% CI)	1.16 [0.87, 1.56]
5 Proportion of cycles with spotting and breakthrough bleeding within 3 cycles	1	2763	Odds Ratio (M‐H, Random, 95% CI)	0.71 [0.31, 1.61]
6 Proportion of cycles with spotting within 6 cycles	1	5235	Odds Ratio (M‐H, Random, 95% CI)	1.17 [0.97, 1.41]
7 Proportion of cycles with spotting within 6 cycles	1	3060	Odds Ratio (M‐H, Random, 95% CI)	0.34 [0.27, 0.44]
8 Proportion of cycles with breakthrough bleeding within 6 cycles	1	5235	Odds Ratio (M‐H, Random, 95% CI)	1.13 [0.91, 1.42]
9 Proportion of cycles with breakthrough bleeding within 6 cycles	1	3060	Odds Ratio (M‐H, Random, 95% CI)	0.41 [0.23, 0.71]
10 Proportion of cycles with spotting and breakthrough bleeding within 6 cycles	2	8295	Odds Ratio (M‐H, Random, 95% CI)	0.50 [0.29, 0.86]
11 Proportion of cycles with spotting within 12 cycles	1	5478	Odds Ratio (M‐H, Random, 95% CI)	1.19 [0.99, 1.44]
12 Proportion of cycles with breakthrough bleeding within 12 cycles	1	5478	Odds Ratio (M‐H, Random, 95% CI)	1.09 [0.88, 1.35]
13 Proportion of cycles with spotting and breakthrough bleeding within 12 cycles	1	5478	Odds Ratio (M‐H, Random, 95% CI)	0.64 [0.33, 1.22]
14 Proportion of women with staining/spotting within 12 cycles	1	197	Odds Ratio (M‐H, Random, 95% CI)	1.55 [0.42, 5.67]
15 Proportion of women with moderate flow intermenstrual bleeding within 12 cycles	1	197	Odds Ratio (M‐H, Random, 95% CI)	2.61 [0.49, 13.77]
16 Proportion of women with spotting at cycle 3	1	894	Odds Ratio (M‐H, Random, 95% CI)	1.18 [0.74, 1.90]
17 Proportion of women with breakthrough bleeding at cycle 3	1	894	Odds Ratio (M‐H, Random, 95% CI)	1.10 [0.66, 1.82]
18 Proportion of women with spotting and breakthrough bleeding at cycle 3	1	894	Odds Ratio (M‐H, Random, 95% CI)	0.50 [0.04, 5.50]
19 Proportion of women with spotting at cycle 6	1	797	Odds Ratio (M‐H, Random, 95% CI)	1.33 [0.68, 2.58]
20 Proportion of women with breakthrough bleeding at cycle 6	1	797	Odds Ratio (M‐H, Random, 95% CI)	1.53 [0.80, 2.92]
21 Proportion of women with spotting and breakthrough bleeding at cycle 6	1	797	Odds Ratio (M‐H, Random, 95% CI)	0.50 [0.04, 5.51]
22 Proportion of women with spotting at cycle 12	1	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
23 Proportion of women with breakthrough bleeding at cycle 12	1	10	Odds Ratio (M‐H, Random, 95% CI)	1.0 [0.03, 33.32]
24 Proportion of women with spotting and breakthrough bleeding at cycle 12	1	10	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
25 Proportion of cycles with amenorrhea within 3 cycles	1	2763	Odds Ratio (M‐H, Random, 95% CI)	1.06 [0.82, 1.39]
26 Proportion of cycles with amenorrhea within 6 cycles	1	5235	Odds Ratio (M‐H, Random, 95% CI)	1.07 [0.87, 1.31]
27 Proportion of cycles with amenorrhea within 6 cycles	1	3060	Odds Ratio (M‐H, Random, 95% CI)	0.21 [0.06, 0.74]
28 Proportion of cycles with amenorrhea within 12 cycles	1	5478	Odds Ratio (M‐H, Random, 95% CI)	1.05 [0.86, 1.28]
29 Proportion of women with amenorrhea within 12 cycles	1	197	Odds Ratio (M‐H, Random, 95% CI)	1.53 [0.25, 9.37]
30 Proportion of women with amenorrhea at cycle 3	1	894	Odds Ratio (M‐H, Random, 95% CI)	1.00 [0.63, 1.57]
31 Proportion of women with amenorrhea at cycle 6	1	797	Odds Ratio (M‐H, Random, 95% CI)	1.35 [0.76, 2.43]
32 Proportion of women with amenorrhea at cycle 12	1	10	Odds Ratio (M‐H, Random, 95% CI)	1.0 [0.03, 33.32]
33 Total discontinuation within 3 cycles	1	948	Odds Ratio (M‐H, Random, 95% CI)	0.80 [0.50, 1.28]
34 Discontinuation due to medical reasons within 3 cycles	1	948	Odds Ratio (M‐H, Random, 95% CI)	0.71 [0.42, 1.19]
35 Discontinuation due to cycle disturbances within 3 cycles	1	948	Odds Ratio (M‐H, Random, 95% CI)	0.73 [0.33, 1.61]
36 Total discontinuation within 6 cycles	2	1503	Odds Ratio (M‐H, Random, 95% CI)	1.00 [0.75, 1.33]
37 Discontinuation due to medical reasons within 6 cycles	2	1503	Odds Ratio (M‐H, Random, 95% CI)	0.71 [0.36, 1.43]
38 Discontinuation due to cycle disturbances within 6 cycles	1	948	Odds Ratio (M‐H, Random, 95% CI)	1.05 [0.58, 1.92]
39 Total discontinuation within 12 cycles	1	197	Odds Ratio (M‐H, Random, 95% CI)	1.44 [0.81, 2.57]
40 Discontinuation due to medical reasons within 12 cycles	1	197	Odds Ratio (M‐H, Random, 95% CI)	1.45 [0.44, 4.72]
41 Discontinuation due to cycle disturbances within 12 cycles	1	197	Odds Ratio (M‐H, Random, 95% CI)	7.29 [0.37, 143.08]