Comparison 11. Triphasic GTD 50‐70‐100 μg and EE 30‐40‐30 μg versus monophasic DSG 150 μg and EE 30 μg.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pregnancy per woman within 6 cycles	1	480	Odds Ratio (M‐H, Random, 95% CI)	2.77 [0.11, 68.38]
2 Pregnancy per woman within 12 cycles	1	168	Odds Ratio (M‐H, Random, 95% CI)	1.0 [0.06, 16.26]
3 Proportion of cycles with spotting within 6 cycles	1	2515	Odds Ratio (M‐H, Random, 95% CI)	0.96 [0.72, 1.28]
4 Proportion of cycles with breakthrough bleeding within 6 cycles	1	2515	Odds Ratio (M‐H, Random, 95% CI)	0.82 [0.48, 1.43]
5 Proportion of cycles with spotting and breakthrough bleeding within 6 cycles	1	2515	Odds Ratio (M‐H, Random, 95% CI)	0.49 [0.33, 0.73]
6 Proportion of women with spotting at cycle 3	2	579	Odds Ratio (M‐H, Random, 95% CI)	1.13 [0.54, 2.33]
7 Proportion of women with breakthrough bleeding at cycle 3	1	160	Odds Ratio (M‐H, Random, 95% CI)	2.85 [0.73, 11.17]
8 Proportion of women with breakthrough bleeding (with or without spotting) at cycle 3	1	419	Odds Ratio (M‐H, Random, 95% CI)	0.73 [0.33, 1.60]
9 Proportion of women with spotting at cycle 6	2	510	Odds Ratio (M‐H, Random, 95% CI)	1.03 [0.50, 2.12]
10 Proportion of women with breakthrough bleeding at cycle 6	1	158	Odds Ratio (M‐H, Random, 95% CI)	1.0 [0.36, 2.81]
11 Proportion of women with breakthrough bleeding (with or without spotting) at cycle 6	1	352	Odds Ratio (M‐H, Fixed, 95% CI)	0.57 [0.20, 1.65]
12 Proportion of women with spotting at cycle 12	1	144	Odds Ratio (M‐H, Random, 95% CI)	1.5 [0.40, 5.56]
13 Proportion of women with breakthrough bleeding at cycle 12	1	144	Odds Ratio (M‐H, Random, 95% CI)	0.97 [0.27, 3.51]
14 Proportion of cycles with amenorrhea within 6 cycles	1	2403	Odds Ratio (M‐H, Random, 95% CI)	0.60 [0.17, 2.14]
15 Proportion of cycles with amenorrhea within 12 cycles	1	2515	Odds Ratio (M‐H, Random, 95% CI)	0.64 [0.20, 2.01]
16 Proportion of women with amenorrhea at cycle 3	2	579	Odds Ratio (M‐H, Random, 95% CI)	1.30 [0.15, 11.52]
17 Proportion of women with amenorrhea at cycle 6	2	510	Odds Ratio (M‐H, Random, 95% CI)	0.49 [0.04, 5.56]
18 Proportion of women with amenorrhea at cycle 12	2	160	Odds Ratio (M‐H, Random, 95% CI)	0.31 [0.03, 3.10]
19 Total discontinuation within 6 cycles	2	648	Odds Ratio (M‐H, Random, 95% CI)	0.89 [0.59, 1.35]
20 Discontinuation due to medical reasons within 6 cycles	1	480	Odds Ratio (M‐H, Random, 95% CI)	0.87 [0.49, 1.54]
21 Discontinuation due to cycle disturbances within 6 cycles	1	480	Odds Ratio (M‐H, Random, 95% CI)	0.76 [0.23, 2.53]
22 Total discontinuation within 12 cycles	1	168	Odds Ratio (M‐H, Random, 95% CI)	0.82 [0.35, 1.96]
23 Discontinuation due to medical reasons within 12 cycles	1	168	Odds Ratio (M‐H, Random, 95% CI)	2.02 [0.18, 22.76]