2. Acute Toxicity Grade III‐IV.

Site of toxicity	No. of trials	Add events (patients)/n	Control (patients)/n	OR (95% CI)
ASSESSABLE PATIENTS
Trials with toxicity defined by WHO criteria Grade III and IV
Alopecia	1	0/51	2/54
Leucopenia*	7	224/517	166/494	1.51 (1.17‐1.95)
Nausea/Vomiting**	4	53/282	23/271	2.50 (1.48‐4.18)
Trials with criteria not defined. Trial grades the toxicity as 'severe'
Alopecia	3	96/118	52/117	5.45 (3.02‐9.84)
Leucopenia*	0	0	0
Nausea/Vomiting**	4	52/286	40/280	1.33 (0.85‐2.09)
If it is assumed that trials which defined toxicity as 'severe' have assessed toxicity the same as trials with toxicity WHO criteria grade III or IV, then these results can be combined (as below)
All trials
Alopecia	4	96/169	54/171	2.85 (1.83‐4.44)
Leucopenia*	7	224/517	166/494	1.51 (1.17‐1.95)
Nausea/Vomiting**	8	105/568	63/551	1.76 (1.25‐2.46)
* data on grade III or IV neutropenia was included if data on leucopenia not reported
**data on vomiting included if nausea and vomiting reported separately