| Trial Name |
Arm I |
Arm II |
| Ahmann 1976a |
Arm I: AC = doxorubicin 40 mg/m2 and cyclophosphamide 500 mg/m2 both day 1. Cycles repeated every 5 weeks. Number of cycles not reported. |
Arm II: CAF = cyclophosphamide 400 mg/m2 + doxorubicin 40 mg/m2 (both day 1) + 5‐fluorouracil 150 mg/m2 (day 1‐3). Cycles repeated every 5 weeks. Number of cycles not reported. |
| Ahmann 1976b |
Arm I: CFP = cyclophosphamide 150 mg/m2 + 5‐fluorouracil 300 mg/m2 both days 1 through 5 + prednisone. Cycles repeated every 5 weeks. Number of cycles not reported. |
Arm II: CAF = cyclophosphamide 400 mg/m2 + doxorubicin 40 mg/m2 (both day 1) + 5‐fluorouracil 150 mg/m2 (day 1‐3). Cycles repeated every 5 weeks. Number of cycles not reported. |
| Aisner 1987a |
Arm I: CAF = cyclophosphamide 100 mg/m2/day days 1‐14 + doxorubicin 25 mg/m2 days 1 & 8 (after total dose of 450 mg/m2 replaced with methotrexate 40 mg/m2 days 1 & 8)+ 5‐fluorouracil 500 mg/m2 days 1 & 8. 28 day cycle. |
Arm II: CAFVP = cyclophosphamide 100 mg/m2/day, days 1‐14 + doxorubicin 25 mg/m2 days 1 & 8 (after total dose 450 mg/m2 replaced with methotrexate 40 mg/m2 days 1 & 8) + 5‐fluorouracil 500 mg/m2 days 1 & 8 + vincristine 10 mg/m2 days 1 & 8 + prednisone 40 mg/m2/day days 1‐14. 28 day cycle. |
| Aisner 1987b |
Arm I: CAF+MER = cyclophosphamide 100 mg/m2/day days 1‐14 + doxorubicin 25 mg/m2 days 1 & 8 (after total dose of 450 mg/m2 replaced with methotrexate 40 mg/m2 days 1 & 8) + 5‐fluorouracil 500 mg/m2 days 1 & 8 + MER 200 micrograms days 1 & 8. 28 day cycle. |
Arm II: CAFVP+MER = cyclophosphamide 100 mg/m2/day, days 1‐14 + doxorubicin 25 mg/m2 days 1 & 8 (after total dose 450 mg/m2 replaced with methotrexate 40 mg/m2 days 1 & 8) + 5‐fluorouracil 500 mg/m2 days 1 & 8 + vincristine 10 mg/m2 days 1 & 8 + prednisone + MER 200 micrograms days 1 & 8. 28 day cycle. |
| Cavalli 1983a |
Arm I: CLB+MFP = chlorambucil 5 mg/m2/day days 1‐14 + methotrexate 10 mg/m2/wk days 1 & 8 + 5‐fluorouracil 500 mg/m2/wk days 1 & 8 + prednisone. 4 weeks cycles for 6 months. |
Arm II: CLB+AMFP = chlorambucil 5 mg/m2/day days 1‐14 + methotrexate 40 mg/m2/wk days 1 & 8 + 5‐fluorouracil 600 mg/m2/wk days 1 & 8 + prednisone 30 mg/m2/day days 1‐14 (then decreasing) + doxorubicin 60 mg/m2 day 28. 8 week cycles for 6 months. |
| Cavalli 1983b |
Arm I: CLB+MFP = chlorambucil 5 mg/m2/day days 1‐14 + methotrexate 10 mg/m2/wk days 1 & 8 + 5‐fluorouracil 500 mg/m2/wk days 1 & 8 + prednisone. 4 weeks cycles for 6 months. |
Arm II: CLB+MFVP = chlorambucil 5 mg/m2/day days 1‐14 + methotrexate 15 mg/m2/wk days 1‐3 & 8‐10 + 5‐fluorouracil 500 mg/m2/wk days 15 & 22 + vincristine 1.2 mg/m2/wk days 15 & 22 + prednisone. 4 week continuous cycle for 6 months. |
| Chlebowski 1983 |
Arm I: A‐CCNU = doxorubicin (25‐40 mg/m2) every 3 weeks + CCNU (65‐90 mg/m2) every 6 weeks. |
Arm II: A‐CCNU‐V = doxorubicin (25‐40 mg/m2) every 3 weeks + CCNU (65‐90 mg/m2) every 6 weeks + vincristine (1.4 mg/m2 with individual dosage not exceeding 2 mg) every 3 weeks. |
| Creech 1979 |
Arm I: CMF = cyclophosphamide 50 mg/m2 days 1‐14 + methotrexate 20 mg/m2 days 1 & 8 + 5‐fluorouracil 300 mg/m2 days 1 & 8. 28 day cycle. |
Arm II: CAMF = cyclophosphamide 50 mg/m2 days 1‐14 + doxorubicin 20 mg/m2 days 1 & 8 + methotrexate 20 mg/m2 days 1 & 8 + 5‐fluorouracil 300 mg/m2 days 1 & 8. 28 day cycle. |
| Cummings 1981a |
Arm I: AV = doxorubicin 60 mg/m2 + vincristine 1.2 mg/m2; Cycles repeated every 3 weeks until progressive disease |
Arm II: AVD = doxorubicin 45 mg/m2 + vincristine 1.2 mg/m2 + dibromodulcitol 140 mg/m2. Cycles repeated every 4 weeks (AVD) until progressive disease. |
| Cummings 1981b |
Arm I: AV = doxorubicin 60 mg/m2 + vincristine 1.2 mg/m2; Cycles repeated every 3 weeks until progressive disease |
Arm II: AVI = doxorubicin 45 mg/m2 + vincristine 1.2 mg/m2 + ICRF‐159 250 mg/m2. Cycles repeated every 4 weeks (AVI) until progressive disease. |
| Inoue 1984 |
Arm I: ACF = doxorubicin 40 mg/m2 day 1 + cyclophosphamide 130 mg/m2 day 1‐5 + ftorafur 500 mg/m2 daily, 21 day cycle. |
Arm II: ACFM = doxorubicin 40 mg/m2 day 1 + cyclophosphamide 130 mg/m2 day 1‐5 + ftorafur 500 mg/m2 daily + methotrexate 10‐15 mg/m2 day 1 & 5, 21 day cycle. |
| Kennealey 1978 |
Arm I: AC = doxorubicin 40 mg/m2 + cyclophosphamide 1.0 mg/m2
|
Arm II: ACMF = doxorubicin 40 mg/m2 + cyclophosphamide 1.0 mg/m2 + methotrexate 30‐40 mg/m2 + 5‐fluorouracil 400‐600 mg/m2. |
| Lokich 1977 |
Arm I: MA = melphalan 2.0 mg/m2 + doxorubicin 50 mg/m2. |
Arm II: MAC = melphalan 1.0 mg/m2 + doxorubicin 50 mg/m2 + cyclophosphamide 250 mg/m2 ‐ to maximum dose doxorubicin 450 mg/m2, then maintenance CMF every 4 weeks. |
| Marschke 1989 |
Arm I: CFP = cyclophosphamide 150 mg/m2 + 5‐fluorouracil 300 mg/m2 + prednisone. |
Arm II: CMFP = cyclophosphamide 100 mg/m2 + methotrexate 40 mg/m2 (< 65 yrs; 30 mg/m2 if ≥ 65 yrs) + 5‐fluorouracil 600 mg/m2 (< 65 yrs; 400 mg/m2 if ≥ 65 yrs) + prednisone. |
| Nemoto 1982a |
Arm I: CFP = cyclophosphamide 150 mg/m2 days 1‐5 + 5‐fluorouracil 300 mg/m2 days 1‐5 + prednisone. Number of cycles not specified. |
Arm II: CFP‐CA = Alternating regimens: cyclophosphamide 150 mg/m2 days 1‐5 + 5‐flurouracil 300 mg/m2 days 1‐5 + prednisone. 5 week cycle then cyclophosphamide 500 mg/m2 + doxorubicin 40 mg/m2 every nine weeks. Maximum cumulative dose of Adriamycin 500 mg/m2. |
| Nemoto 1982b |
Arm I: AC = doxorubicin 40 mg/m2 day 1 + cyclophosphamide 500 mg/m2 day 1. |
Arm II: CAF = cyclophosphamide 400 mg/m2 day 1 + 5‐fluorouracil 200 mg/m2 days 1‐3 + doxorubicin 40 mg/m2 day 1. |
| Pannuti 1984 |
Arm I: CMF = cyclophosphamide 100 mg/m2 days 1‐14 + methotrexate 40 mg/m2 day 1 & 8 + 5‐fluorouracil 600 mg/m2 day 1 & 8. 28 day cycle. |
Arm II: R14 = cyclophosphamide 2 mg/kg + vincristine 0.01 mg/kg + vinblastine 0.1 mg/kg all on day 1 and then on day 2, 5‐fluorouracil 5 mg/kg + methotrexate 0.7 mg/kg + doxorubicin 0.5 mg/kg. Cycle every 21 days. |
| Rosner 1989 |
Arm I: CFP = cyclophosphamide 150 mg/m2 + 5‐fluorouracil 300mg/m2 + prednisone every 5 weeks. |
Arm II: CFPMV = 5‐fluorouracil 500 mg + methotrexate 25 mg + vincristine 1 mg (all weekly) + cyclophosphamide 50 mg + prednisone. |
| Segaloff 1985 |
Arm I: CMFP = cyclophosphamide 100 mg/day + methotrexate 25 mg/week + 5‐fluorouracil 500 mg/week + prednisone. |
Arm II: CMFVP = cyclophosphamide 100 mg/day + methotrexate 25 mg/week + 5‐fluorouracil 500 mg/week + vincristine 1 mg/week + prednisone. |
| Stein 1992 |
Arm I: 2M = mitozantrone 6.5 mg/m2, methotrexate 30 mg/m2 every 3 weeks. |
Arm II: 3M = mitozantrone 6.5 mg/m2, methotrexate 30 mg/m2 every 3 weeks & mitomycin C 6.5 mg/m2 every 6 weeks. |
| Tranum 1982 |
Arm I: AC = doxorubicin 40 mg/m2 + cyclophosphamide 200 mg/m2 (p.o) on day 3, 4, 5, 6 every 3 weeks for 3 courses, then ever 4 weeks. Number of cycles not reported |
Arm II: FAC = doxorubicin 50 mg/m2 + cyclophosphamide 500 mg/m2 + 5‐fluorouracil 500 mg/m2 every 4 weeks |
| Vogel 1984 |
Arm I: CAF = cyclophosphamide 500 mg/m2 + doxorubicin 50 mg/m2 + 5‐fluorouracil 500 mg/m2. 3 week cycle |
Arm II: CAF+CAMELEON = CAF (as arm I) alternating cycle with CAMELEON at 3 weekly intervals. CAMELEON: vincristine 1.4 mg/m2 + methotrexate 30 mg/m2 (three additional doses of per os methotrexate given at 6 hourly intervals) + cytosine arabinoside 300 mg/m2 + leucovorin 17.5 mg/m2. |
