Comparison 3. Overall response (assessable patients).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Overall response (all trials)	20	2101	Odds Ratio (M‐H, Fixed, 95% CI)	1.21 [1.01, 1.44]
3.2 Overall response (sensitivity analysis)	16	1682	Odds Ratio (M‐H, Fixed, 95% CI)	1.38 [1.14, 1.68]
3.3 Overall response (addition of 'less active' drug vs addition of 'more active' drug)	20		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.3.1 Addition of 'less active' drug	6	659	Odds Ratio (M‐H, Fixed, 95% CI)	1.03 [0.74, 1.43]
3.3.2 Addition of 'more active' drug	14	1518	Odds Ratio (M‐H, Fixed, 95% CI)	1.34 [1.09, 1.65]
3.4 Overall response (adjusted dose in addition of a drug arm vs no dose adjustment)	20		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.4.1 Dose adjusted in addition of drug arm	12	1381	Odds Ratio (M‐H, Fixed, 95% CI)	1.27 [1.01, 1.58]
3.4.2 Dose not adjusted in addition of drug arm	8	722	Odds Ratio (M‐H, Fixed, 95% CI)	1.10 [0.81, 1.50]
3.5 Overall response (addition of anthracycline vs addition of non‐anthracycline)	20		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.5.1 Addition of an anthracycline	5	352	Odds Ratio (M‐H, Fixed, 95% CI)	1.87 [1.22, 2.86]
3.5.2 Addition of a non‐anthracycline	15	1847	Odds Ratio (M‐H, Fixed, 95% CI)	1.13 [0.94, 1.37]
3.6 Overall response (addition of 1 agent vs addition of 2 or more agents)	20		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.6.1 Addition of 1 agent	16	1772	Odds Ratio (M‐H, Fixed, 95% CI)	1.22 [1.01, 1.48]
3.6.2 Addition of 2 or more agents	4	331	Odds Ratio (M‐H, Fixed, 95% CI)	1.12 [0.70, 1.81]